Crosstalk between Oxidative Stress and Ferroptosis/Oxytosis in Ischemic Stroke: Possible Targets and Molecular Mechanisms

被引：138

作者：

Ren, Jia-Xin ^{[1
,2
,3
]}

Li, Chao ^{[1
,2
,3
]}

Yan, Xiu-Li ^{[1
,2
,3
]}

Qu, Yang ^{[1
,2
,3
]}

Yang, Yi ^{[1
,2
,3
,4
]}

Guo, Zhen-Ni ^{[1
,2
,3
,4
]}

机构：

[1] Jilin Univ, Hosp 1, Stroke Ctr, 1 Xinmin St, Changchun 130021, Peoples R China

[2] Jilin Univ, Hosp 1, Clin Trial & Res Ctr Stroke, Dept Neurol, 1 Xinmin St, Changchun 130021, Peoples R China

[3] China Natl Comprehens Stroke Ctr, 1 Xinmin St, Changchun 130021, Peoples R China

[4] Jilin Prov Key Lab Cerebrovasc Dis, 1 Xinmin St, Changchun 130021, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2021年 / 2021卷

基金：

中国国家自然科学基金;

关键词：

HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; AMINO-ACID-CONCENTRATIONS; TRANSCRIPTION FACTOR NRF2; CELL-DEATH; GLUTAMATE TOXICITY; LIPID-PEROXIDATION; GLYCINE ANTAGONIST; NEURONAL DEATH; IN-VITRO; BRAIN;

D O I：

10.1155/2021/6643382

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxidative stress is a key cause of ischemic stroke and an initiator of neuronal dysfunction and death, mainly through the overproduction of peroxides and the depletion of antioxidants. Ferroptosis/oxytosis is a unique, oxidative stress-induced cell death pathway characterized by lipid peroxidation and glutathione depletion. Both oxidative stress and ferroptosis/oxytosis have common molecular pathways. This review summarizes the possible targets and the mechanisms underlying the crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke. This knowledge might help to further understand the pathophysiology of ischemic stroke and open new perspectives for the treatment of ischemic stroke.

引用

页数：13

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