Hepatitis C virus acquisition among Egyptians: analysis of a 10-year surveillance of acute hepatitis C

被引:31
|
作者
Mohsen, Amira [1 ]
Bernier, Adeline [2 ]
LeFouler, Lenaig [2 ]
Delarocque-Astagneau, Elisabeth [2 ]
El-Daly, Mai [3 ,4 ,5 ]
El-Kafrawy, Sherif [3 ,4 ,5 ]
El-Mango, Salwa [6 ]
Abdel-Hamid, Mohamed [4 ,7 ]
Gadallah, Mohsen [8 ]
Esmat, Gamal [9 ]
Mohamed, Mostafa K. [8 ]
Fontanet, Arnaud [2 ,10 ]
机构
[1] Natl Res Ctr, Dept Community Med, Cairo, Egypt
[2] Inst Pasteur, Emerging Dis Epidemiol Unit, Paris, France
[3] Menoufia Univ, Natl Liver Inst, Menoufia, Egypt
[4] Natl Hepatol & Trop Med Res Inst, Viral Hepatitis Res Lab, Cairo, Egypt
[5] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21413, Saudi Arabia
[6] Alexandria Fever Hosp, Alexandria, Egypt
[7] Minia Univ, Fac Med, Al Minya, Egypt
[8] Ain Shams Univ, Fac Med, Cairo, Egypt
[9] Cairo Univ, Endem Med Dept, Fac Med, Cairo, Egypt
[10] Conservatoire Natl Arts & Metiers, Chaire Sante & Dev, Paris, France
关键词
acute hepatitis C; risk factors; epidemiology; Egypt; hepatite C aigue; facteurs de risque; epidemiologie; Egypte; hepatitis C aguda; factores de riesgo; epidemiologia; Egipto; RISK-FACTORS; DRUG-USERS; INFECTION; HCV; TRANSMISSION; EPIDEMIOLOGY; PREVALENCE; SPOUSES; SPREAD; BURDEN;
D O I
10.1111/tmi.12410
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
ObjectiveTo identify current risk factors for hepatitis C virus (HCV) acquisition among Egyptians. MethodsPatients with acute HCV were identified through a surveillance system of acute hepatitis in four fever hospitals in Egypt between 2002 and 2012. Case-control analysis was conducted, cases being incident acute symptomatic HCV and controls being acute hepatitis A identified at the same hospitals. The questionnaire covered iatrogenic, community and household exposures to HCV in the 1-6months prior to onset of symptoms. Multivariate models were built to identify risk factors associated with HCV acquisition among non-drug users and drug users separately. ResultsAmong non-drug users, hospital admission was independently associated with acute HCV infection (OR=4.2, 95% CI=1.7-10.5). Several iatrogenic procedures, for example admission in a surgery unit, sutures, IV injections and IV infusions, highly correlated with hospital admission, were also associated with acute HCV infection and could have been used in the final model instead of hospital admission. Among drug users, identified risk factors were multiple sexual relations (OR=4.0, 95% CI=1.1-14.7), intravenous drug use (OR=3.9, 95% CI=1.2-13.0) and shaving at the barbershops (OR=8.7, 95% CI=2.4-31.4). Illiteracy and marriage were significant risk factors in both groups. ConclusionInvasive medical procedures are still a major risk for acquiring new HCV infections in Egypt, as is illicit drug use in spreading HCV infection. ObjectifIdentifier les facteurs de risque actuels pour l'acquisition du virus de l'hepatite C (VHC) chez les Egyptiens. MethodesLes patients atteints du VHC aigue ont ete identifies grace a un systeme de surveillance de l'hepatite aigue dans quatre hopitaux de la fievre en Egypte entre 2002 et 2012. Une analyse cas-temoins a ete realisee, les cas etant des incidents symptomatiques de VHC aigue et les temoins, des cas d'hepatite A aigue identifies dans les memes hopitaux. Le questionnaire portait sur les expositions iatrogenes, familiales et communautaires au VHC entre un a six mois avant l'apparition des symptomes. Des modeles multivaries ont ete construits pour identifier les facteurs de risque associes a l'acquisition du VHC chez les non-toxicomanes et les toxicomanes separement. ResultatsParmi les non-toxicomanes, l'admission a l'hopital etait independamment associee a l'infection aigue par le VHC (OR = 4,2; IC95% = 01,07 a 10,05). Plusieurs procedures iatrogenes, par exemple, l'admission dans une unite de chirurgie, les sutures, les injections IV, les perfusions IV, correlaient fortement avec l'admission a l'hopital, etaient egalement associees a l'infection par le VHC aigue et auraient pu etre utilisees dans le modele final plutot que l'admission a l'hopital. Parmi les usagers de drogues, les facteurs de risque identifies etaient des relations sexuelles multiples (OR = 4,0; IC95% = 1,1 a 14,7), l'utilisation de drogues par voie intraveineuse (OR = 3,9; IC95% = 1,2 a 13,0) et le rasage chez le barbier (OR = 8,7; IC95% = 2,4 a 31,4). L'analphabetisme et le mariage etaient des facteurs de risque importants dans les deux groupes. ConclusionLes procedures medicales invasives sont toujours un risque majeur pour l'acquisition de nouvelles infections par le VHC en Egypte, ainsi que l'utilisation de drogues illicites dans la propagation de l'infection par le VHC. ObjetivoIdentificar los factores de riesgo actuales para la adquisicion del virus de la hepatitis C (VHC) entre Egipcios. MetodosSe identificaron pacientes con VHC aguda mediante un sistema de vigilancia de hepatitis aguda en cuatro hospitales en Egipto, entre el 2002 y 2012. Se realizo un analisis de caso-control, en el que los casos eran pacientes con VHC aguda sintomaticos y los controles pacientes con hepatitis A aguda, identificados en los mismos hospitales. El cuestionario cubria exposiciones iatrogenicas, comunitarias y dentro del hogar al VHC entre uno y seis meses antes del inicio de los sintomas. Se construyeron modelos multinomiales para identificar los factores de riesgo asociados a la adquisicion del VHC entre consumidores de drogas y no consumidores de forma separada. ResultadosEntre los no consumidores, la admision hospitalaria estaba independiente asociada con una infeccion aguda por el VHC (OR=4.2, IC 95% =1.7-10.5). Varios procedimientos iatrogenicos, por ejemplo la admision en una unidad quirurgica, las suturas, las inyecciones intravenosas (IV), o las infusiones IV, estaban altamente correlacionadas con la admision hospitalaria al igual que con la infeccion aguda por VHC y podrian haberse utilizado en el modelo final en vez de la admision hospitalaria. Entre los usuarios de drogas, los factores de riesgo identificados eran multiples relaciones sexuales (OR=4.0, IC 95% =1.1-14.7), uso de drogas intravenosas (OR=3.9, IC 95% =1.2-13.0) y afeitarse en el barbero (OR=8.7, IC 95% =2.4-31.4). El analfabetismo y el matrimonio eran factores de riesgo significativos en ambos grupos. ConclusionLos procedimientos medicos invasivos continuan siendo un factor de riesgo importante para la adquisicion de nuevas infecciones por VHC en Egipto, al igual que el uso de drogas ilicitas lo es para diseminar la infeccion.
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页码:89 / 97
页数:9
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