Actomyosin contraction, aggregation and traveling waves in a treadmilling actin array
被引:7
作者:
Oelz, Dietmar
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NYU, Courant Inst Math Sci, 251 Mercer St, New York, NY 10012 USANYU, Courant Inst Math Sci, 251 Mercer St, New York, NY 10012 USA
Oelz, Dietmar
[1
]
Mogilner, Alex
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NYU, Courant Inst Math Sci, 251 Mercer St, New York, NY 10012 USA
NYU, Dept Biol, 550 1St Ave, New York, NY 10012 USANYU, Courant Inst Math Sci, 251 Mercer St, New York, NY 10012 USA
Mogilner, Alex
[1
,2
]
机构:
[1] NYU, Courant Inst Math Sci, 251 Mercer St, New York, NY 10012 USA
[2] NYU, Dept Biol, 550 1St Ave, New York, NY 10012 USA
We use perturbation theory to derive a continuum model for the dynamic actomyosin bundle/ring in the regime of very strong crosslinking. Actin treadmilling is essential for contraction. Linear stability analysis and numerical solutions of the model equations reveal that when the actin treadmilling is very slow, actin and myosin aggregate into equidistantly spaced peaks. When treadmilling is significant, actin filament of one polarity are distributed evenly, while filaments of the opposite polarity develop a shock wave moving with the treadmilling velocity. Myosin aggregates into a sharp peak surfing the crest of the actin wave. Any actomyosin aggregation diminishes contractile stress. The easiest way to maintain higher contraction is to upregulate the actomyosin turnover which destabilizes nontrivial patterns and stabilizes the homogeneous actomyosin distributions. We discuss the model's implications for the experiment. (C) 2015 Elsevier B.V. All rights reserved.
机构:
Technion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
Technion Israel Inst Technol, Russell Berrie Nanotechnol Inst, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
Abu Shah, Enas
Keren, Kinneret
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Technion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
Technion Israel Inst Technol, Russell Berrie Nanotechnol Inst, IL-32000 Haifa, Israel
Technion Israel Inst Technol, Network Biol Res Labs, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
机构:
Univ Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Carvalho, Ana
Desai, Arshad
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Univ Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Desai, Arshad
Oegema, Karen
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Univ Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
机构:
Technion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
Technion Israel Inst Technol, Russell Berrie Nanotechnol Inst, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
Abu Shah, Enas
Keren, Kinneret
论文数: 0引用数: 0
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机构:
Technion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
Technion Israel Inst Technol, Russell Berrie Nanotechnol Inst, IL-32000 Haifa, Israel
Technion Israel Inst Technol, Network Biol Res Labs, IL-32000 Haifa, IsraelTechnion Israel Inst Technol, Dept Phys, IL-32000 Haifa, Israel
机构:
Univ Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Carvalho, Ana
Desai, Arshad
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h-index: 0
机构:
Univ Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
Desai, Arshad
Oegema, Karen
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h-index: 0
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Univ Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Cellular & Mol Med, Ludwig Inst Canc Res, La Jolla, CA 92093 USA