Clinical outcomes in patients with T4 laryngeal cancer treated with primary radiotherapy versus primary laryngectomy

被引：31

作者：

Vengalil, Salil ^{[1
,6
]}

Giuliani, Meredith E. ^{[1
]}

Huang, Shao Hui ^{[1
]}

McNiven, Andrea ^{[2
]}

Song, Yuyao ^{[3
]}

Xu, Wei ^{[3
]}

Chan, Biu ^{[1
]}

Hope, Andrew ^{[1
]}

Cho, John ^{[1
]}

Bayley, Andrew ^{[1
]}

Ringash, Jolie ^{[1
]}

Goldstein, David ^{[4
]}

Razak, Albiruni ^{[5
]}

Irish, Jonathan ^{[4
]}

Gilbert, Ralph ^{[4
]}

Gullane, Patrick ^{[4
]}

Waldron, John ^{[1
]}

Kim, John ^{[1
]}

O'Sullivan, Brian ^{[1
]}

机构：

[1] Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Oncol, Toronto, ON, Canada

[2] Univ Toronto, Princess Margaret Canc Ctr, Dept Radiat Phys, Toronto, ON, Canada

[3] Univ Toronto, Princess Margaret Canc Ctr, Dept Biostat, Toronto, ON, Canada

[4] Univ Toronto, Princess Margaret Canc Ctr, Dept Otolaryngol Head & Neck Surgery Surg Oncol, Toronto, ON, Canada

[5] Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol, Toronto, ON, Canada

[6] Univ Hosp North Midlands NHS Trust, Royal Stoke Univ Hosp, Dept Clin Oncol, Stoke On Trent, Staffs, England

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷

关键词：

laryngeal carcinoma; chemoradiotherapy; laryngectomy; organ preservation; Dosimetric analysis; QUALITY-OF-LIFE; SQUAMOUS-CELL CARCINOMA; LOCALLY ADVANCED HEAD; TUMOR VOLUME; DEFINITIVE RADIOTHERAPY; NONSURGICAL TREATMENT; COMPUTED-TOMOGRAPHY; NECK; CHEMOTHERAPY; PREDICTOR;

D O I：

10.1002/hed.24374

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The purpose of this study was to determine the clinical outcomes of T4 laryngeal cancers. Methods. T4 laryngeal cancers treated with curative intent from January 2003 to December 2010 were analyzed. Outcomes were evaluated in both primary radiotherapy (+/- chemotherapy) (RT/CRT) and primary surgery cohorts. Results. Among the 65 primary RT/CRT and 42 primary surgery patients included, median follow-up was 4.4 years. There was a trend for improved locoregional control with surgery (74% vs 88%; p = .08). In the RT/CRT group the 3-year laryngectomy-free survival was 67%. The 2-year gastrostomy dependency rate was 23% with RT/CRT versus 6% with primary surgery (p = .07). Overall survival (OS) at 3 years was significantly lower in the RT/CRT versus primary surgery group (41% vs 70%; p < .01). Conclusion. Laryngeal preservation is achieved in over two thirds of patients with primary RT/CRT. Patients with low volume minimal cartilage involvement T4 disease may be best suited to RT/CRT. (C) 2016 Wiley Periodicals, Inc.

引用

页码：E2035 / E2040

页数：6

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