Effectiveness of a mass hepatitis A vaccination program in preadolescents

被引：47

作者：

Domínguez, A ^{[1
]}

Salleras, L ^{[1
]}

Carmona, G ^{[1
]}

Batalla, J ^{[1
]}

机构：

[1] Generalitat Catalonia, Gen Dicectorate Publ Hlth, Dept Hlth & Social Secur, Barcelona 08028, Spain

来源：

VACCINE | 2003年 / 21卷 / 7-8期

关键词：

hepatitis A plus B vaccine; effectiveness; hepatitis A incidence;

D O I：

10.1016/S0264-410X(02)00583-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A program of mass hepatitis A + B vaccination in preadolescents in schools was begun in the Catalonia in the last quarter of 1998. This study investigated the impact of the program by comparing the incidence of hepatitis A in vaccinated and unvaccinated cohort. The greatest reduction of the incidence rate of hepatitis A was observed in the 10-14 years age group, from 10.3 per 100,000 persons-year in the period 1996-1998 to 1.8 per 100,000 persons-year in the period 1999-2001. The global incidence decreased from 6.2 to 2.6 per 100,000 persons-year. After analysis of cases occurring in the vaccinated and non vaccinated cohort, the effectiveness of the vaccination program was estimated at 97.0% (95% Cl: 78.6-99.6). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：698 / 701

页数：4

共 14 条

[1] [Anonymous], MODERN INFECT DIS EP
[2] Hepatitis A virus infections in the United States: Model-based estimates and implications for childhood immunization
Armstrong, GL
Bell, BP
[J]. PEDIATRICS, 2002, 109 (05) : 839 - 845
[3] Control of hepatitis A through routine vaccination of children
Averhoff, F
Shapiro, CN
Bell, BP
Hyams, I
Burd, L
Deladisma, A
Simard, EP
Nalin, D
Kuter, B
Ward, C
Lundberg, M
Smith, N
Margolis, HS
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (23): : 2968 - 2973
[4] BADER TF, 1995, VIRAL HEPATITIS PRAC
[5] The cost of hepatitis A infections in American adolescents and adults in 1997
Berge, JJ
Drennan, DP
Jacobs, RJ
Jakins, A
Meyerhoff, AS
Stubblefield, W
Weinberg, M
[J]. HEPATOLOGY, 2000, 31 (02) : 469 - 473
[6] BRANCOFF WH, 1992, NEW ENGL J MED, V327, P448
[7] *CDC, 2001, MMWR-MORBID MORTAL W, V48, P84
[8] Clinical course and consequences of hepatitis A infection
Ciocca, M
[J]. VACCINE, 2000, 18 : S71 - S74
[9] *HLTH CAN, 2001, CAN COMMUN DIS REP, V2756, P110
[10] PROTECTION AGAINST HEPATITIS-A BY AN INACTIVATED VACCINE
INNIS, BL
SNITBHAN, R
KUNASOL, P
LAORAKPONGSE, T
POOPATANAKOOL, W
KOZIK, CA
SUNTAYAKORN, S
SUKNUNTAPONG, T
SAFARY, A
TANG, DB
BOSLEGO, JW
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (17): : 1328 - 1334

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