Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice

被引：7
作者：
Goya, Rocio Laguna [1 ]
Tyers, Pam [1 ]
Barker, Roger A. [1 ,2 ,3 ]
机构：
[1] Cambridge Ctr Brain Repair, Cambridge, England
[2] Addenbrookes Hosp, Dept Neurol, Cambridge, England
[3] Edith Cowan Univ, Perth, WA, Australia
来源：
NEUROREPORT | 2010年 / 21卷 / 05期
基金：
英国医学研究理事会;
关键词：
adult neurogenesis; major histocompatibility complex class I; TAP1 knockout mouse; water maze; HIPPOCAMPAL NEUROGENESIS; DENTATE GYRUS; CELLS; PLASTICITY; MOLECULES; NEURONS; MEMORY; CNS;
D O I：
10.1097/WNR.0b013e3283377463
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The major histocompatibility complex (MHC) class I has a role in the regulation of immune responses and has been implicated recently in neural plasticity and neurogenesis. We therefore sought to investigate in functional MHC class I knockout mice, transporter associated with antigen processing 1 (TAP1) KO, whether there are alterations in adult neurogenesis. We found no significant differences in cell proliferation or neurogenesis in either the dentate gyrus or subventricular zone, in TAP1 KO versus wild-type mice at several different time points. Our results do not support a role for MHC class I in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons. NeuroReport 21:349-353 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：349 / 353
页数：5
相关论文
共 50 条
  • [31] Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction
    Walther, Johanna
    Wilbie, Danny
    Tissingh, Vincent S. J.
    Oktem, Mert
    van der Veen, Heleen
    Lou, Bo
    Mastrobattista, Enrico
    PHARMACEUTICS, 2022, 14 (01)
  • [32] Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice
    Mossa, Adele
    Pagano, Jessica
    Ponzoni, Luisa
    Tozzi, Alessandro
    Vezzoli, Elena
    Sciaccaluga, Miriam
    Costa, Cinzia
    Beretta, Stefania
    Francolini, Maura
    Sala, Mariaelvina
    Calabresi, Paolo
    Boeckers, Tobias M.
    Sala, Carlo
    Verpelli, Chiara
    MOLECULAR PSYCHIATRY, 2021, 26 (06) : 1928 - 1944
  • [33] Attrition of Hepatic Damage Inflicted by Angiotensin II with α-Tocopherol and β-Carotene in Experimental Apolipoprotein E Knock-out Mice
    Gopal, Kaliappan
    Gowtham, Munusamy
    Sachin, Singh
    Ram, Mani Ravishankar
    Shankar, Esaki M.
    Kamarul, Tunku
    SCIENTIFIC REPORTS, 2015, 5
  • [34] Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength
    Mieczkowska, A.
    Mansur, S.
    Bouvard, B.
    Flatt, P. R.
    Thorens, B.
    Irwin, N.
    Chappard, D.
    Mabilleau, G.
    OSTEOPOROSIS INTERNATIONAL, 2015, 26 (01) : 209 - 218
  • [35] LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses
    Wang, Shao-hua
    Huang, Yan
    Yuan, Yang
    Xia, Wen-qing
    Wang, Pin
    Huang, Rong
    LIPIDS IN HEALTH AND DISEASE, 2014, 13
  • [36] Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy
    Chadi, Sead
    Polyte, Jacqueline
    Lefevre, Lucas
    Castille, Johan
    Ehanno, Aude
    Laubier, Johann
    Jaffrezic, Florence
    Le Provost, Fabienne
    PLOS ONE, 2016, 11 (09):
  • [37] Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice
    Gu, YH
    McIlwain, KL
    Weeber, EJ
    Yamagata, T
    Xu, BS
    Antalffy, BA
    Reyes, C
    Yuva-Paylor, L
    Armstrong, D
    Zoghbi, H
    Sweatt, JD
    Paylor, R
    Nelson, DL
    JOURNAL OF NEUROSCIENCE, 2002, 22 (07) : 2753 - 2763
  • [38] Bone-derived extracellular matrix hydrogel from thrombospondin-2 knock-out mice for bone repair
    Chen, Zhuoyue
    Zhang, Junqi
    Lee, Francis Y.
    Kyriakides, Themis R.
    ACTA BIOMATERIALIA, 2024, 186 : 85 - 94
  • [39] Activation of PPARγ Ameliorates Spatial Cognitive Deficits through Restoring Expression of AMPA Receptors in Seipin Knock-Out Mice
    Zhou, Libin
    Chen, Tingting
    Li, Guoxi
    Wu, Chaoming
    Wang, Conghui
    Li, Lin
    Sha, Sha
    Chen, Lei
    Liu, George
    Chen, Ling
    JOURNAL OF NEUROSCIENCE, 2016, 36 (04) : 1242 - 1253
  • [40] Synergistic Roles for G-protein γ3 and γ7 Subtypes in Seizure Susceptibility as Revealed in Double Knock-out Mice
    Schwindinger, William F.
    Mirshahi, Uyenlinh L.
    Baylor, Kelly A.
    Sheridan, Kathleen M.
    Stauffer, Anna M.
    Usefof, Stephanie
    Stecker, Mark M.
    Mirshahi, Tooraj
    Robishaw, Janet D.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (10) : 7121 - 7133
12345