VASCULAR COMPLEXITY ANALYSIS IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF DIABETIC RETINOPATHY

被引:25
作者
Alam, Minhaj [1 ]
Le, David [1 ]
Lim, Jennifer, I [2 ]
Yao, Xincheng [1 ,2 ]
机构
[1] Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA
[2] Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL USA
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2021年 / 41卷 / 03期
关键词
vascular complexity; diabetic retinopathy; medical imaging; ophthalmology; optical coherence tomography; optical diagnostics for medicine; physiology; visual system; noninvasive assessment; SICKLE-CELL RETINOPATHY; FOVEAL AVASCULAR ZONE; VESSEL DENSITY; FEATURES; EYES;
D O I
10.1097/IAE.0000000000002874
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: This study aimed to verify the feasibility of using vascular complexity features for objective differentiation of controls and nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) patients. Methods: This was a cross-sectional study conducted in a tertiary, subspecialty, academic practice. The cohort included 20 control subjects, 60 NPDR patients, and 56 PDR patients. Three vascular complexity features, including the vessel complexity index, fractal dimension, and blood vessel tortuosity, were derived from each optical coherence tomography angiography image. A shifting-window measurement was further implemented to identify local feature distortions due to localized neovascularization and mesh structures in PDR. Results: With mean value analysis of the whole-image, only the vessel complexity index and blood vessel tortuosity were able to classify NPDR versus PDR patients. Comparative shifting-window measurement revealed increased sensitivity of complexity feature analysis, particularly for NPDR versus PDR classification. A multivariate regression model indicated that the combination of all three vascular complexity features with shifting-window measurement provided the best classification accuracy for controls versus NPDR versus PDR. Conclusion: Vessel complexity index and blood vessel tortuosity were the most sensitive in differentiating NPDR and PDR patients. A shifting-window measurement increased the sensitivity significantly for objective optical coherence tomography angiography classification of diabetic retinopathy.
引用
收藏
页码:538 / 545
页数:8
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