Biguanides: Species with versatile therapeutic applications

被引：58

作者：

Kathuria, Deepika ^{[1
]}

Raul, Akshay D. ^{[2
]}

Wanjari, Pravin ^{[2
]}

Bharatam, Prasad, V ^{[2
]}

机构：

[1] Chandigarh Univ, Univ Ctr Res & Dev, Gharuan 140413, Punjab, India

[2] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Sect 67, Sas Nagar 160062, Punjab, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 219卷

关键词：

Biguanide; Metformin; Anticancer activity; Antiviral activity; Antimalarial activity; POLYCYSTIC-OVARY-SYNDROME; HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVATED PROTEIN-KINASE; TYPE-2; DIABETES-MELLITUS; POLYNITROGEN STRONG BASES; RECYCLABLE HETEROGENEOUS NANOCATALYST; CANCER CELL-PROLIFERATION; DIVALENT N(I) CHARACTER; DENTAL PLAQUE REDUCTION; PEPTIDASE-IV ACTIVITY;

D O I：

10.1016/j.ejmech.2021.113378

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Biguanides are compounds in which two guanidine moieties are fused to form a highly conjugated system. Biguanides are highly basic and hence they are available as salts mostly hydrochloride salts, these cationic species have been found to exhibit many therapeutic properties. This review covers the research and development carried out on biguanides and accounts the various therapeutic applications of drugs containing biguanide group-such as antimalarial, antidiabetic, antiviral, anticancer, antibacterial, antifungal, anti-tubercular, anti-filarial, anti-HIV, as well as other biological activities. The aim of this review is to compile all the medicinal chemistry applications of this class of compounds so as to pave way for the accelerated efforts in finding the drug action mechanisms associated with this class of compounds. Importance has been given to the organic chemistry of these biguanide derivatives also. (C) 2021 Elsevier Masson SAS. All rights reserved.

引用

页数：39

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