EFFECTS OF CARBOHYDRATE INGESTION ON ACUTE LEUKOCYTE, CORTISOL, AND INTERLEUKIN-6 RESPONSE IN HIGH-INTENSITY LONG-DISTANCE RUNNING

被引:11
作者
Ihalainen, Johanna K. [1 ]
Vuorimaa, Timo [2 ]
Puurtinen, Risto [1 ]
Hamalainen, Ismo [3 ]
Mero, Antti A. [1 ]
机构
[1] Univ Jyvaskyla, Dept Biol Phys Act, SF-40100 Jyvaskyla, Finland
[2] Haaga Helia Univ Appl Sci, Vierumaki, Finland
[3] Finnish Athlet Federat, Helsinki, Finland
关键词
endurance exercise; sport drink; cortisol; white blood cell count; IL-6; NEUTROPHIL DEGRANULATION RESPONSES; SKELETAL-MUSCLE; IMMUNE FUNCTION; PLASMA CYTOKINE; MESSENGER-RNA; 2.5; H; EXERCISE; SUPPLEMENTATION; SYSTEM; ADAPTATION;
D O I
10.1519/JSC.0000000000000470
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Ihalainen, JK, Vuorimaa, T, Puurtinen, R, Hamalainen, I and Mero, AA. Effects of carbohydrate ingestion on acute leukocyte, cortisol, and interleukin-6 response in high-intensity long-distance running. J Strength Cond Res 28(10): 2786-2792, 2014The purpose of this study was to investigate the effect of ingestion of fluids with different carbohydrate concentrations (0, 1.5, and 7%) on the acute immune stress responses after high-intensity long-distance running. Continuous 18- to 20-km run was performed at 75% of maximal oxygen uptake with carbohydrate supplementation (CHO7%, 7% carbohydrate solution) and low-carbohydrate supplementation (lowCHO1.5%, 1.5% carbohydrate solution) in a randomized, double-blind, placebo (PLA) controlled design. Seven recreational runners (4 men and 3 women) completed all 3 trials. Blood was collected at baseline (PRE) and immediately after the run (POST). The running task induced significant (p 0.05) increases in leukocyte (white blood cells), neutrophil, and interleukin-6 (IL-6) counts in every trial. There was a significant (p 0.05) increase in cortisol with PLA and lowCHO1.5% but not with CHO7%. Increase in total leukocyte and neutrophil concentration was significantly lower with CHO7% compared with PLA (p 0.05). Postexercise IL-6 levels were significantly elevated when compared with baseline in all conditions (p 0.05). Interleukin-6 (IL-6) concentrations did not differ significantly between trials. LowCHO1.5% sport drink did not significantly differ from PLA in measured variables, which indicated that the amount and rate of carbohydrate ingestion (15 g, 10 gh(-1)) in low-carbohydrate sport drink was not enough to significantly protect from the stress induced by high-intensity long-distance running, whereas the ingestion of CHO7% (45 gh(-1)) blunted the significant cortisol response and significantly decreased the leukocyte response.
引用
收藏
页码:2786 / 2792
页数:7
相关论文
共 36 条
[1]   THE ACUTE-PHASE RESPONSE [J].
BAUMANN, H ;
GAULDIE, J .
IMMUNOLOGY TODAY, 1994, 15 (02) :74-80
[2]   Nutritional aspects of immunosuppression in athletes [J].
Bishop, NC ;
Blannin, AK ;
Walsh, NP ;
Robson, PJ ;
Gleeson, M .
SPORTS MEDICINE, 1999, 28 (03) :151-176
[3]   Influence of carbohydrate supplementation on plasma cytokine and neutrophil degranulation responses to high intensity intermittent exercise [J].
Bishop, NC ;
Gleeson, M ;
Nicholas, CW ;
Ali, A .
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 2002, 12 (02) :145-156
[4]   Carbohydrate beverage ingestion and neutrophil degranulation responses following cycling to fatigue at 75% VO2 max [J].
Bishop, NC ;
Blannin, AK ;
Walsh, NP ;
Gleeson, M .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 2001, 22 (03) :226-231
[5]   Carbohydrates for training and competition [J].
Burke, Louise M. ;
Hawley, John A. ;
Wong, Stephen H. S. ;
Jeukendrup, Asker E. .
JOURNAL OF SPORTS SCIENCES, 2011, 29 :S17-S27
[6]  
CANNON JG, 2001, HDB OXIDANTS ANTIOXI, P177
[7]   DETERMINATION OF THE ANAEROBIC THRESHOLD BY A NON-INVASIVE FIELD-TEST IN RUNNERS [J].
CONCONI, F ;
FERRARI, M ;
ZIGLIO, PG ;
DROGHETTI, P ;
CODECA, L .
JOURNAL OF APPLIED PHYSIOLOGY, 1982, 52 (04) :869-873
[8]   CORTICOSTEROID-MEDIATED IMMUNOREGULATION IN MAN [J].
CUPPS, TR ;
FAUCI, AS .
IMMUNOLOGICAL REVIEWS, 1982, 65 :133-155
[9]   Muscle-derived interleukin-6: mechanisms for activation and possible biological roles [J].
Febbraio, MA ;
Pedersen, BK .
FASEB JOURNAL, 2002, 16 (11) :1335-1347
[10]   Neuroendocrine-Immune Interactions and Responses to Exercise [J].
Fragala, Maren S. ;
Kraemer, William J. ;
Denegar, Craig R. ;
Maresh, Carl M. ;
Mastro, Andrea M. ;
Volek, Jeff S. .
SPORTS MEDICINE, 2011, 41 (08) :621-639