Viral shape-shifting: norovirus evasion of the human immune system

被引：214

作者：

Donaldson, Eric F.

Lindesmith, Lisa C.

Lobue, Anna D.

Baric, Ralph S. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 03期

基金：

美国国家卫生研究院;

关键词：

BLOOD GROUP ANTIGENS; EQUINE ENCEPHALITIS-VIRUS; NORWALK-LIKE VIRUSES; INFECTIOUS NONBACTERIAL GASTROENTERITIS; ROUND-STRUCTURED VIRUSES; HUMAN CALICIVIRUS MEXICO; UNITED-STATES; REPLICON PARTICLES; P2; DOMAIN; MOLECULAR CHARACTERIZATION;

D O I：

10.1038/nrmicro2296

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Noroviruses are the most common cause of food-borne gastroenteritis worldwide, and explosive outbreaks frequently occur in community settings, where the virus can immobilize large numbers of infected individuals for 24-48 hours, making the development of effective vaccines and antiviral therapies a priority. However, several challenges have hampered therapeutic design, including: the limitations of cell culture and small-animal model systems; the complex effects of host pre-exposure histories; differential host susceptibility, which is correlated with blood group and secretor status; and the evolution of novel immune escape variants. In this Review, we discuss the molecular and structural mechanisms that facilitate the persistence of noroviruses in human populations.

引用

页码：231 / 241

页数：11

共 96 条

[61] Alphavirus-Adjuvanted Norovirus-Like Particle Vaccines: Heterologous, Humoral, and Mucosal Immune Responses Protect against Murine Norovirus Challenge [J].