Viral shape-shifting: norovirus evasion of the human immune system

被引：214
作者：
Donaldson, Eric F.
Lindesmith, Lisa C.
Lobue, Anna D.
Baric, Ralph S. [1 ]
机构：
[1] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 03期
基金：
美国国家卫生研究院;
关键词：
BLOOD GROUP ANTIGENS; EQUINE ENCEPHALITIS-VIRUS; NORWALK-LIKE VIRUSES; INFECTIOUS NONBACTERIAL GASTROENTERITIS; ROUND-STRUCTURED VIRUSES; HUMAN CALICIVIRUS MEXICO; UNITED-STATES; REPLICON PARTICLES; P2; DOMAIN; MOLECULAR CHARACTERIZATION;
D O I：
10.1038/nrmicro2296
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Noroviruses are the most common cause of food-borne gastroenteritis worldwide, and explosive outbreaks frequently occur in community settings, where the virus can immobilize large numbers of infected individuals for 24-48 hours, making the development of effective vaccines and antiviral therapies a priority. However, several challenges have hampered therapeutic design, including: the limitations of cell culture and small-animal model systems; the complex effects of host pre-exposure histories; differential host susceptibility, which is correlated with blood group and secretor status; and the evolution of novel immune escape variants. In this Review, we discuss the molecular and structural mechanisms that facilitate the persistence of noroviruses in human populations.
引用
收藏
页码：231 / 241
页数：11
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