Dynamics of serum antibodies to and load of porcine circovirus type 2 (PCV2) in pigs in three finishing herds, affected or not by postweaning multisystemic wasting syndrome

被引:17
|
作者
Brunborg, Inger M. [1 ]
Fossum, Caroline [2 ]
Lium, Bjorn [1 ,5 ]
Blomqvist, Gunilla [3 ]
Merlot, Elodie [2 ,4 ]
Jorgensen, Anne [5 ]
Eliasson-Selling, Lena [6 ]
Rimstad, Espen [7 ]
Jonassen, Christine M. [1 ]
Wallgren, Per [3 ,8 ]
机构
[1] Natl Vet Inst, N-0106 Oslo, Norway
[2] Swedish Univ Agr Sci SLU, Immunol Sect, BVF, SE-75123 Uppsala, Sweden
[3] Natl Vet Inst, SVA, SE-75189 Uppsala, Sweden
[4] INRA, UMR1079, F-35000 Rennes, France
[5] Norwegian Pig Hlth Serv, N-0513 Oslo, Norway
[6] Swedish Anim Hlth Serv, S-75323 Uppsala, Sweden
[7] Norwegian Sch Vet Sci, N-0033 Oslo, Norway
[8] Swedish Univ Agr Sci SLU, Dept Clin Sci, SE-75007 Uppsala, Sweden
关键词
SYNDROME PMWS; RISK-FACTORS; SWEDISH ISOLATE; REPRODUCTION; PATHOGENESIS; INFECTION; IMMUNITY; PIGLETS; DISEASE; VIREMIA;
D O I
10.1186/1751-0147-52-22
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Background: Despite that PMWS commonly affects pigs aged eight to sixteen weeks; most studies of PMWS have been conducted during the period before transfer to finishing herds. This study focused on PCV2 load and antibody dynamics in finishing herds with different PMWS status. Methods: Sequentially collected blood samples from 40 pigs in each of two Swedish (A and B) and one Norwegian (C) finishing herds were analysed for serum PCV2-load and -antibodies and saliva cortisol. The two Swedish herds differed in PMWS status, despite receiving animals from the same sow pool (multi-site production). However, the PMWS-deemed herd (A) had previously also received pigs from the spot market. ResultsThe initial serum PCV2 load was similar in the two Swedish herds. In herd A, it peaked after two weeks in the finishing herd and a high number of the pigs had serum PCV2 levels above 10(7) per ml. The antibody titres increased continually with exception for the pigs that developed PMWS, that had initially low and then declining antibody levels. Pigs in the healthy herd B also expressed high titres of antibodies to PCV2 on arrival but remained at that level throughout the study whereas the viral load steadily decreased. No PCV2 antibodies and only low amounts of PCV2 DNA were detected in serum collected during the first five weeks in the PMWS-free herd C. Thereafter a peak in serum PCV2 load accompanied by an antibody response was recorded. PCV2 from the two Swedish herds grouped into genotype PCV2b whereas the Norwegian isolate grouped into PCV2a. Cortisol levels were lower in herd C than in herds A and B. Conclusions: The most obvious difference between the Swedish finishing herds and the Norwegian herd was the time of infection with PCV2 in relation to the time of allocation, as well as the genotype of PCV2. Clinical PMWS was preceded by low levels of serum antibodies and a high load of PCV2 but did not develop in all such animals. It is notable that herd A became affected by PMWS after errors in management routine, emphasising the importance of proper hygiene and general disease-preventing measures.
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页数:10
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