Combination of RNA Interference and Stem Cells for Treatment of Central Nervous System Diseases

被引：1

作者：

Hou, Xue-Qin ^{[1
]}

Wang, Lei ^{[1
]}

Wang, Fu-Gang ^{[1
]}

Zhao, Xiao-Min ^{[1
]}

Zhang, Han-Ting ^{[1
,2
,3
]}

机构：

[1] Taishan Med Univ, Inst Pharmacol, Tai An 271016, Shandong, Peoples R China

[2] West Virginia Univ, Hlth Sci Ctr, Blanchette Rockefeller Neurosci Inst, Dept Behav Med & Psychiat, Morgantown, WV 26506 USA

[3] West Virginia Univ, Hlth Sci Ctr, Blanchette Rockefeller Neurosci Inst, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA

来源：

GENES | 2017年 / 8卷 / 05期

关键词：

RNA interference; miRNA pathway; stem cells; differentiation; central nervous system diseases; SPINAL-CORD-INJURY; PROMOTES NEURONAL DIFFERENTIATION; NEURAL STEM/PROGENITOR CELLS; ALZHEIMERS-DISEASE; THERAPEUTIC-EFFICACY; NOGO RECEPTOR; FUNCTIONAL RECOVERY; COGNITIVE FUNCTION; MEDIATED DELIVERY; IMPROVE COGNITION;

D O I：

10.3390/genes8050135

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RNA interference (RNAi), including microRNAs, is an important player in the mediation of differentiation and migration of stem cells via target genes. It is used as a potential strategy for gene therapy for central nervous system (CNS) diseases. Stem cells are considered vectors of RNAi due to their capacity to deliver RNAi to other cells. In this review, we discuss the recent advances in studies of RNAi pathways in controlling neuronal differentiation and migration of stem cells. We also highlight the utilization of a combination of RNAi and stem cells in treatment of CNS diseases.

引用

页数：14

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