Highly Efficient Visible-Light-Driven [2+2] Cycloaddition of Maleimides to Alkenes and Alkynes for the Synthesis of 3-Azabicyclo[3.2.0]heptane-Fused Scaffolds

被引：11

作者：

He, Jian ^{[1
]}

Liu, Qiang ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 04期

基金：

中国国家自然科学基金;

关键词：

visible light sensitization; energy transfer; photocatalysis; cycloadditions; 3-azabicyclo[3.2.0]heptanes; ACID-DERIVATIVES; AMINO-ACIDS; PHOTOCYCLOADDITION; TRANSFORMATIONS; PHOTOCHEMISTRY; PHOTOCATALYSIS;

D O I：

10.1055/a-1480-3215

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient [2+2] cycloaddition between maleimides and unsaturated moieties, utilizing a visible-light triplet sensitization mode, has been developed for the direct synthesis of multifunctional 3-azabicyclo[3.2.0]heptane derivatives. This reaction relies on selective activation of the maleimide functionality upon energy transfer from a new photosensitizer that outperforms diverse well-established photosensitizers. The strategy developed herein overcomes previous obstacles such as limited substrate scope and undesired reaction pathways under harsh UV irradiation.

引用

页码：925 / 942

页数：18

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