Alternative RNA Splicing in the Pathogenesis of Liver Disease

被引：34

作者：

Webster, Nicholas J. G. ^{[1
,2
]}

机构：

[1] VA San Diego Healthcare Syst, Med Res Serv, San Diego, CA 92161 USA

[2] Univ Calif San Diego, Sch Med, Dept Med, Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2017年 / 8卷

关键词：

non-alcoholic fatty liver disease; RNA splicing; hepatocellular carcinoma; splicing factors; microarrays; HEPATITIS-B-VIRUS; TRACT-BINDING-PROTEIN; HEPATOCELLULAR-CARCINOMA; MYOTONIC-DYSTROPHY; MECHANISMS; GENE; TRANSCRIPTOME; EXPRESSION; SEQUENCE; GENOME;

D O I：

10.3389/fendo.2017.00133

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent due to the worldwide obesity epidemic and currently affects one-third of adults or about one billion people worldwide. NAFLD is predicted to affect over 50% of the world's population by the end of the next decade. It is the most common form of liver disease and is associated with increased risk for progression to a more severe form non-alcoholic steatohepatitis, as well as insulin resistance, type 2 diabetes mellitus, cirrhosis, and eventually hepatocellular carcinoma. This review article will focus on the role of alternative splicing in normal liver physiology and dysregulation in liver disease.

引用

页数：9

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