Cyclodextrin-piroxicam inclusion complexes: analyses by mass spectrometry and molecular modelling

被引：30

作者：

Gallagher, RT ^{[1
]}

Ball, CP

Gatehouse, DR

Gates, PJ

Lobell, M

Derrick, PJ

机构：

[1] Hunting Life Sci, Huntington PE18 6ES, Cambs, England

[2] Univ Warwick, Inst Mass Spectrometry, Coventry CV4 7AL, W Midlands, England

[3] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 1997年 / 165卷

关键词：

cyclodextrin; piroxicam; inclusion complex; non-covalent interaction; molecular modelling;

D O I：

10.1016/S0168-1176(97)00178-X

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Mass spectrometry has been used to investigate the natures of non-covalent complexes formed between the anti-inflammatory drug piroxicam and alpha-, beta- and gamma-cyclodextrins, Energies of these complexes have been calculated by means of molecular modelling. There is a correlation between peak intensities in the mass spectra and the calculated energies. (C) 1997 Elsevier Science B.V.

引用

页码：523 / 531

页数：9

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