Strategies to treat patients with antibiotic resistant Helicobacter pylori

被引:12
作者
Mégraud, F [1 ]
机构
[1] Hop Pellegrin, Bacteriol Lab, F-33076 Bordeaux, France
关键词
Helicobacter pylori; proton pump inhibitor; treatment strategies;
D O I
10.1016/S0924-8579(00)00286-7
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Increased resistance to clarithomycin and metronidazole, the two main antibiotics used to treat Helicobacter pylori infection, has led to a search for alternatives to the proton pump inhibitor based triple therapies commonly used. The main rescuse therapy is a bismuth-based quadruple therapy. However, triple therapies with tetracycline and metronidazole or amoxicillin and metronidazole can be considered in the case of clarithomycin resistance. They can also be used in the case of metronidazole resistance by increasing the dose and duration of metronidazole. The only therapy without clarithomycin and metronidazole includes rifabutin and amoxicillin. Dual therapies with amoxicillin and a proton pump inhibitor at high dose can also be used. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:507 / 509
页数:3
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