Sleep alterations and iron deficiency anemia in infancy

被引：40

作者：

Peirane, Patricio D. ^{[1
]}

Algarin, Cecilia R. ^{[1
]}

Chamorro, Rodrigo A. ^{[1
]}

Reyes, Sussanne C. ^{[1
]}

Duran, Samuel A. ^{[1
]}

Garrido, Marcelo I. ^{[1
]}

Lozoff, Betsy ^{[2
]}

机构：

[1] Univ Chile, INTA, Sleep & Funct Neurobiol Lab, Santiago, Chile

[2] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA

来源：

SLEEP MEDICINE | 2010年 / 11卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Iron deficiency anemia; Infancy; Sleep; REM sleep; NREM sleep; Childhood; RESTLESS LEGS SYNDROME; CEREBRAL-BLOOD-FLOW; WAKE CYCLE; SPINDLE ACTIVITY; REM-SLEEP; MATERNAL REPORTS; MOTOR-ACTIVITY; BRAIN; NUCLEUS; STATES;

D O I：

10.1016/j.sleep.2010.03.014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Iron deficiency anemia (IDA) continues to be the most common single nutrient deficiency in the world. An estimated 20-25% of the world's infants have IDA, with at least as many having iron deficiency without anemia. Infants are at particular risk due to rapid growth and limited dietary sources of iron. We found that infants with IDA showed different motor activity patterning in all sleep-waking states and several differences in sleep states organization. Sleep alterations were still apparent years after correction of anemia with iron treatment in the absence of subsequent IDA. We suggest that altered sleep patterns may represent an underlying mechanism that interferes with optimal brain functioning during sleep and wakefulness in former IDA children. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：637 / 642

页数：6

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