Toll-like receptor 4 and atherogenesis

被引：47
作者：
Kiechl, S
Wiedermann, CJ
Willeit, J
机构：
[1] Innsbruck Univ Clin, Dept Neurol, A-6020 Innsbruck, Austria
[2] Innsbruck Univ Clin, Dept Internal Med, A-6020 Innsbruck, Austria
来源：
ANNALS OF MEDICINE | 2003年 / 35卷 / 03期
关键词：
atherosclerosis; cardiovascular disease; endotoxin; genetics; heatshock protein; infection; inflammation; innate immunity; Toll-like receptor;
D O I：
10.1080/07853890310008215
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Toll-like receptor 4 (TLR4) is a pattern recognition receptor involved in the innate immune response to various microorganisms and other exogenous and endogenous stress factors. Recently, evidence emerged that important inflammatory processes implicit in human atherogenesis are mediated in part via the TLR4/nuclear factor-kappaB pathway. Polymorphisms of TLR4, which attenuate receptor signalling, enhance the risk of acute severe infections but may have opposite effects on atherogenesis. The aim of this review is to critically discuss current experimental and epidemiological evidence for a role of TLR4 in atherogenesis and to highlight the main controversies and perspectives in this emerging field of vascular biology.
引用
收藏
页码：164 / 171
页数：8
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