Noncoding RNAs in Unexplained Recurrent Spontaneous Abortions and Their Diagnostic Potential

被引：20

作者：

Jia, Ningyi ^{[1
]}

Li, Jian ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing, Peoples R China

来源：

DISEASE MARKERS | 2019年 / 2019卷

关键词：

HUMAN CHORIONIC VILLI; CIRCULATING MICRORNAS; DIFFERENTIAL EXPRESSION; TROPHOBLAST INVASION; PREGNANCY LOSS; MISCARRIAGE; CELLS; APOPTOSIS; PREECLAMPSIA; POLYMORPHISM;

D O I：

10.1155/2019/7090767

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Unexplained recurrent spontaneous abortion (URSA) is defined as the loss of two or more consecutive pregnancies before the 20th week of gestation with normal findings on routine screening tests. Our understanding of the cellular and molecular pathogenesis of URSA is still far from complete. Noncoding RNAs (ncRNAs) play a pivotal role in transcription and expression. The functions of ncRNAs may also improve understanding of URSA pathogenesis. Because of their stability in the circulatory system and at the maternal-fetal interface, it may be possible to use ncRNAs as biomarkers for certain disease states. Here, we provide a narrative review of the current state of knowledge about ncRNAs associated with URSA. The possibility of developing a diagnostic tool using ncRNAs is discussed. The underlying mechanisms of how ncRNAs may lead to the onset of URSA are explored in this review.

引用

页数：7

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