Genetic Characterization of a Captive Colony of Pigtailed Macaques (Macaca nemestrina)

被引：0

作者：

Zhang, Xinjun ^{[1
,2
]}

Kanthaswamy, Sree ^{[3
]}

Trask, Jessica S. ^{[1
,2
]}

Ng, Jillian ^{[1
,2
]}

Oldt, Robert F. ^{[3
]}

Mankowski, Joseph L. ^{[4
,5
]}

Adams, Robert J. ^{[4
]}

Smith, David G. ^{[1
,2
]}

机构：

[1] Univ Calif Davis, Dept Anthropol, Davis, CA 95616 USA

[2] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA

[3] Arizona State Univ, Sch Math & Nat Sci, Glendale, AZ USA

[4] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA

[5] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

来源：

JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE | 2017年 / 56卷 / 04期

关键词：

RHESUS MACAQUES; MITOCHONDRIAL-DNA; VIRUS-INFECTIONS; CHIMERIC VIRUS; MULATTA; POPULATIONS; MONKEYS; MANAGEMENT; CHINESE; MODEL;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Effective colony management is critical to guarantee the availability of captive NHP as subjects for biomedical research. Pigtailed macaques (Macaca nemestrina) are an important model for the study of human and nonhuman primate diseases and behavior. Johns Hopkins University hosts one of the largest captive colonies of pigtailed macaques in the United States. In this study, we used 56 single-nucleotide polymorphisms (SNP) to characterize this population of pigtailed macaques, understand their population structure, and assess the effectiveness of their colony management. The results demonstrate that the colony has maintained a high level of genetic diversity, with no loss of heterozygosity since its origin, and low levels of inbreeding and genetic subdivision.

引用

页码：390 / 395

页数：6

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