Reflections on the usefulness of today's atrial fibrillation ablation procedure endpoints and patient-reported outcomes

被引：11

作者：

Blomstrom-Lundqvist, Carina ^{[1
]}

Wettervik, Victoria Svedung ^{[1
]}

机构：

[1] Uppsala Univ, Dept Med Sci, S-75185 Uppsala, Sweden

来源：

EUROPACE | 2022年 / 24卷 / SUPPL 2期

关键词：

Atrial fibrillation; Ablation; Quality-of-life; Symptom; Drug; Outcome; Patient-reported outcome; QUALITY-OF-LIFE; ANTIARRHYTHMIC-DRUG THERAPY; PULMONARY-VEIN ABLATION; RADIOFREQUENCY CATHETER ABLATION; HEALTH-CARE UTILIZATION; RHYTHM-CONTROL; SYMPTOM SEVERITY; ELECTRICAL CARDIOVERSION; CRYOBALLOON ABLATION; 1ST-LINE TREATMENT;

D O I：

10.1093/europace/euab318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The improvement of Patient-reported outcomes, such as health-related quality of life, is the main indication for atrial fibrillation ablation. Despite this guideline derived indication for an AF ablation procedure the current standardized primary endpoint in AF ablation trials is still rhythm-related, and primarily a 30-second long AF episode. The review presents reflections on the non-rational arguments of using rhythm related endpoints rather than Patient-reported outcomes in AF ablation procedure trials despite the mismatch between many of the rhythm related variables and symptoms. Arguments for health-related quality of life as the most optimal primary endpoint in clinical trials are presented while atrial fibrillation burden is presented as the most optimal electrical complementary endpoint, apart from being the major variable in mechanistic trials.

引用

页码：29 / 43

页数：15

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