Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements

被引：25
|
作者：
Wang, Jianfeng [1 ]
Zheng, Wei [1 ,2 ]
Lin, Kan [1 ,2 ]
Huang, Zhiwei [1 ]
机构：
[1] Natl Univ Singapore, Fac Engn, Dept Biomed Engn, Opt Bioimaging Lab, Singapore 117576, Singapore
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119260, Singapore
来源：
OPTICS LETTERS | 2016年 / 41卷 / 13期
基金：
英国医学研究理事会;
关键词：
DIFFERENT ANATOMICAL SITES; CHARACTERIZING VARIABILITY; DIAGNOSIS; CARIES;
D O I：
10.1364/OL.41.003045
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We report on the development of a unique sideview hand-held hybrid Raman spectroscopy (RS) and optical coherence tomography (OCT) technique for real-time in vivo tissue measurements. A sideview handheld RS-OCT optical probe is designed to coalign the optical paths of RS and OCT sampling arms, whereby a compact long-pass dichroic mirror (LPDM) is utilized to transmit the OCT signal through a gradient index rod lens and a reflection mirror, whereas the LPDM deflects the tissue Raman signal by 90 degrees, leading to coaligned RS/OCT optical samplings on the tissue. Further study shows that the hybrid RS and OCT technique developed is capable of simultaneously acquiring both morphological and biochemical information about the oral tissue in vivo, facilitating real-time, in vivo tissue diagnoses and characterizations in the oral cavity. (C) 2016 Optical Society of America
引用
收藏
页码：3045 / 3048
页数：4
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