Evidence of graft-versus-Waldenstrom's macroglobulinaemia effect after allogeneic stem cell transplantation: a single centre experience

被引：10

作者：

Stakiw, J. ^{[1
]}

Kim, D. H. ^{[1
]}

Kuruvilla, J. ^{[1
]}

Gupta, V. ^{[1
]}

Messner, H. ^{[1
]}

Lipton, J. H. ^{[1
]}

机构：

[1] Univ Toronto, Princess Margaret Hosp, Allogene BMT Program, Dept Hematol Med Oncol, Toronto, ON M5G 2M9, Canada

来源：

BONE MARROW TRANSPLANTATION | 2007年 / 40卷 / 04期

关键词：

Waldenstrom's macroglobulinaemia; allogeneic peripheral blood stem cell transplantation; graft-versus-Waldenstrom's effect;

D O I：

10.1038/sj.bmt.1705748

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The role of allogeneic stem cell transplantation (SCT) in Waldenstrom's macroglobulinaemia (WM) is not yet clear, as published data on allogeneic SCT in WM are limited. We present a retrospective study of allogeneic SCT in five patients with WM. Median age was 56 years ( range 40-60 years). All patients were heavily pretreated. Conditioning therapy with busulphan and cyclophosphamide was used for all patients and all were given cyclosporine and methotrexate for graft-versus-host disease prophylaxis. With a median follow-up of 32 months ( range 2-43), all except one are alive and disease free. Progressive, delayed decline in serum IgM levels were noted in all the patients, suggesting an active graft-versus Waldenstrom's effect. With the limited available data, it appears that allogeneic SCT is a useful treatment option for advanced WM.

引用

页码：369 / 372

页数：4

共 24 条

[1] Autologous and allogeneic stem cell transplantation in Waldenstrom's macroglobulinemia: Review of the literature and future directions [J].