Clinical and molecular significance of genetic loci associated with psoriatic arthritis

被引：7

作者：

O'Rielly, Darren D. ^{[1
]}

Rahman, Proton ^{[2
]}

机构：

[1] Mem Univ, Fac Med, Craig L Dobbin Genet Res Ctr, Suite 3M500,300 Prince Philip Dr, St John, NF A1B 3V6, Canada

[2] St Clares Mercy Hosp, 154 LeMarchant Rd, St John, NF A1C5B8, Canada

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2021年 / 35卷 / 02期

关键词：

Psoriatic arthritis; Genetics; Genomics; Association studies; Human leukocyte antigen; Pharmacogenetics; Pharmacogenomics; GENOME-WIDE ASSOCIATION; NF-KAPPA-B; TNF-ALPHA; DOUBLE-BLIND; JOINT MANIFESTATIONS; SUSCEPTIBILITY LOCUS; TREATMENT RESPONSE; COMMON VARIANTS; POLYMORPHISMS; RISK;

D O I：

10.1016/j.berh.2021.101691

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Psoriatic arthritis (PsA) is caused by a combination of environmental and multiple genetic factors, with clear evidence for a strong genetic basis. The remarkable accumulation of knowledge gained from genetic, pharmacogenetic, and therapeutic response of biologic agents in PsA has fundamentally changed and advanced our understanding of disease pathogenesis and has identified key signalling pathways. However, only one-quarter of the genetic contribution of PsA has been accounted for; and dissecting the genetic contributors of the cutaneous disease from those that would identify joint disease has been challenging. More importantly, the clinical utility of multiple proposed loci is unclear. In this review, we summarize the potential clinical relevance from established genetic associations and provide insight on the proposed molecular pathways that arise from these associations. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：13

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