The role of RecQ helicases in non-homologous end-joining

被引：18

作者：

Keijzers, Guido ^{[1
]}

Maynard, Scott ^{[1
]}

Shamanna, Raghavendra A. ^{[2
]}

Rasmussen, Lene Juel ^{[1
]}

Croteau, Deborah L. ^{[2
]}

Bohr, Vilhelm A. ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Dept Cellular & Mol Med, Ctr Hlth Aging, Copenhagen, Denmark

[2] NIA, Lab Mol Gerontol, Baltimore, MD 21224 USA

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2014年 / 49卷 / 06期

关键词：

Alternative end-joining; Ku70/80; microhomology-mediated end-joining; non-homologous end-joining; RecQ helicases; telomere; DEPENDENT PROTEIN-KINASE; DOUBLE-STRAND BREAKS; ROTHMUND-THOMSON-SYNDROME; WERNER-SYNDROME PROTEIN; BASE EXCISION-REPAIR; BLOOMS-SYNDROME PROTEIN; RNA-POLYMERASE-II; CLASS SWITCH RECOMBINATION; SYNDROME GENE-PRODUCT; LIGASE-IV COMPLEX;

D O I：

10.3109/10409238.2014.942450

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through their important roles in several DNA repair pathways, including DNA double-strand break repair. Double-strand breaks can be repaired by homologous recombination (HR) using sister chromatids as templates to facilitate precise DNA repair, or by an HR-independent mechanism known as non-homologous end-joining (NHEJ) (error-prone). NHEJ is a non-templated DNA repair process, in which DNA termini are directly ligated. Canonical NHEJ requires DNA-PKcs and Ku70/80, while alternative NHEJ pathways are DNA-PKcs and Ku70/80 independent. This review discusses the role of RecQ helicases in NHEJ, alternative (or back-up) NHEJ (B-NHEJ) and microhomology-mediated end-joining (MMEJ) in V(D)J recombination, class switch recombination and telomere maintenance.

引用

页码：463 / 472

页数：10

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