Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation

被引：8

作者：

Yue WenTao ^{[1
]}

Zhao XiaoTing ^{[1
]}

Zhang LiNa ^{[1
]}

Liu ZhiDong ^{[2
]}

Ma Li ^{[1
]}

Jia WenYun ^{[1
]}

Qian Zhe ^{[1
]}

Zhang ChunYan ^{[1
]}

Wang Yue ^{[1
]}

Yang XueHui ^{[1
]}

Xu ShaoFa ^{[2
]}

机构：

[1] Capital Med Univ, Beijing Chest Hosp, Dept Cellular Biol, Beijing 101149, Peoples R China

[2] Capital Med Univ, Beijing Chest Hosp, Dept Thorac Surg, Beijing 101149, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2010年 / 53卷 / 04期

关键词：

CCNY; NSCLC; lentivirus RNAi; H1299; EXPRESSION; A1;

D O I：

10.1007/s11427-010-0090-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyclin Y (CCNY) is a key cell cycle regulator that acts as a growth factor sensor to integrate extracellular signals with the cell cycle machinery. The expression status of CCNY in lung cancer and its clinical significance remain unknown. The data indicates that CCNY may be deregulated in non-small cell lung cancer, where it may act to promote cell proliferation. These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment.

引用

页码：511 / 516

页数：6

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