Circulating endothelial cells as biomarkers in clinical oncology

被引：46
作者：
Mancuso, Patrizia [1 ]
Bertolini, Francesco [1 ]
机构：
[1] European Inst Oncol, Dept Pathol, Lab Hematol Oncol, I-20141 Milan, Italy
来源：
MICROVASCULAR RESEARCH | 2010年 / 79卷 / 03期
关键词：
Angiogenesis; Endothelial cells; Endothelial progenitors; PROGENITOR CELLS; TUMOR ANGIOGENESIS; SURROGATE MARKER; STEM-CELLS; CANCER; RESISTANCE; KINETICS; BLOOD; MOBILIZATION; INHIBITION;
D O I：
10.1016/j.mvr.2010.02.007
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Circulating endothelial cells (CECs) and circulating endothelial progenitors (CEPs) play a different role in cancer development, acting as possible markers of vascular turnover/damage (CECs) and vasculogenesis (CEPs). Preclinical and clinical data suggest that CEC enumeration might be useful to define the best treatment option for patients who are candidate to anti-angiogenic therapy, while CEPs seem to have a "catalytic" role in different steps of cancer progression and recurrence after therapy. The definition of CEC and CEP phenotype and the standardization of CEC and CEP enumeration procedures are highly warranted to use these cells as biomarkers in clinical trials in oncology, and to compare results from different studies. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：224 / 228
页数：5
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