Asymmetric synthesis of α-aminophosphonates by means of direct organocatalytic three-component hydrophosphonylation

被引：17
|
作者：
Wang Lian [1 ]
Cui ShuMin [2 ]
Meng Wei [1 ]
Zhang GuangWu [1 ]
Nie Jing [1 ]
Ma JunAn [1 ]
机构：
[1] Tianjin Univ, Dept Chem, Tianjin 300072, Peoples R China
[2] Henan Agr Univ, Dept Chem, Zhengzhou 450002, Peoples R China
来源：
CHINESE SCIENCE BULLETIN | 2010年 / 55卷 / 17期
基金：
中国国家自然科学基金;
关键词：
alpha-aminophosphonate; organocatalysis; aromatic aldehyde; three-component reaction; enantioselectivity; CHIRAL BRONSTED ACID; FRIEDEL-CRAFTS REACTION; CATALYZED ENANTIOSELECTIVE HYDROPHOSPHONYLATION; MULTICOMPONENT REACTIONS AMCRS; MANNICH-TYPE REACTION; AMINO-ACIDS; MACROCYCLIC INHIBITORS; METAL CATALYSIS; PHOSPHONATES; IMINES;
D O I：
10.1007/s11434-009-3743-x
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The direct asymmetric three-component reaction of an aromatic (or cinnamic) aldehyde, an amine and a phosphite was investigated by employing chiral Bronsted acid. In general, modest to good enantioselectivities (31%-87% ee) could be obtained in acceptable isolated yields (61%-91%) for a series of substrates.
引用
收藏
页码：1729 / 1731
页数：3
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