Hypervalent Iodine(III)-Catalyzed Balz-Schiemann Fluorination under Mild Conditions

被引：66

作者：

Xing, Bo ^{[1
]}

Ni, Chuanfa ^{[1
]}

Hu, Jinbo ^{[1
]}

机构：

[1] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Ctr Excellence Mol Sy, 345 Ling Ling Rd, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 31期

基金：

中国国家自然科学基金;

关键词：

aryl fluorides; Balz-Schiemann reaction; diazonium salts; fluorination; iodine; COPPER-MEDIATED FLUORINATION; C-H FLUORINATION; NUCLEOPHILIC AROMATIC FLUORINATION; CATALYZED FLUORINATION; ARYL FLUORIDES; SANDMEYER TRIFLUOROMETHYLATION; ELECTROPHILIC FLUORINATION; VICINAL DIFLUORINATION; GEMINAL DIFLUORINATION; FUNCTIONALIZED ARYL;

D O I：

10.1002/anie.201802466

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unprecedented hypervalent iodine(III) catalyzed Balz-Schiemann reaction is described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeds under mild conditions (25-60 degrees C), and features a wide substrate scope and good functional-group compatibility.

引用

页码：9896 / 9900

页数：5

共 94 条

[1] Mild Fluorination of Chloropyridines with in Situ Generated Anhydrous Tetrabutylammonium Fluoride [J].