NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection

被引：18
作者：
Kamada, Anselmo Jiro [1 ]
Pontillo, Alessandra [3 ]
Guimaraes, Rafael Lima [1 ]
Loureiro, Paula [4 ]
Crovella, Sergio [1 ]
Cavalcanti Brandao, Lucas Andre [2 ]
机构：
[1] Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil
[2] Univ Fed Pernambuco, Dept Patol, Recife, PE, Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Imunogenet, BR-05508 Sao Paulo, Brazil
[4] Fundacao Hematol & Hemoterapia Pernambuco, Recife, PE, Brazil
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2014年 / 109卷 / 07期
关键词：
NLRP3; NLRP1; single nucleotide polymorphisms; innate immunity; HTLV-1; CELLS; DISEASE; HTLV-1; SUSCEPTIBILITY; INFLAMMASOME; VITILIGO; RISK; GENE; LOAD; SNP;
D O I：
10.1590/0074-0276140154
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.
引用
收藏
页码：960 / +
页数：5
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