On the mechanism of long-range orientational order of fibroblasts

被引：49

作者：

Li, Xuefei ^{[1
]}

Balagam, Rajesh ^{[2
]}

He, Ting-Fang ^{[3
]}

Lee, Peter P. ^{[3
]}

Igoshin, Oleg A. ^{[1
,2
]}

Levine, Herbert ^{[1
,2
]}

机构：

[1] Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77030 USA

[2] Rice Univ, Dept Bioengn, Houston, TX 77030 USA

[3] City Hope Natl Med Ctr, Dept Immunooncol, Ctr Comprehens Canc, Duarte, CA 91010 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2017年 / 114卷 / 34期

基金：

美国国家科学基金会;

关键词：

alignment; fibroblasts; long-range order; extracellular matrix; collagen fibers; CANCER-ASSOCIATED FIBROBLASTS; COLLAGEN; MATRIX;

D O I：

10.1073/pnas.1707210114

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-range alignment ordering of fibroblasts have been observed in the vicinity of cancerous tumors and can be recapitulated with in vitro experiments. However, the mechanisms driving their ordering are not understood. Here, we show that local collision-driven nematic alignment interactions among fibroblasts are insufficient to explain observed long-range alignment. One possibility is that there exists another orientation field coevolving with the cells and reinforcing their alignment. We propose that this field reflects the mechanical cross-talk between the fibroblasts and the underlying fibrous material on which they move. We show that this long-range interaction can give rise to high nematic order and to the observed patterning of the cancer microenvironment.

引用

页码：8974 / 8979

页数：6

共 34 条

[1] Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts [J].

Amatangelo, MD ;

Bassi, DE ;

Klein-Szanto, AJP ;

Cukierman, E .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (02) :475-488

[2] Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment [J].

Augsten, Martin .

FRONTIERS IN ONCOLOGY, 2014, 4

[3] Mechanism for Collective Cell Alignment in Myxococcus xanthus Bacteria [J].

Balagam, Rajesh ;

Igoshin, Oleg A. .

PLOS COMPUTATIONAL BIOLOGY, 2015, 11 (08)

[4] Stromal fibroblasts in cancer initiation and progression [J].

Bhowmick, NA ;

Neilson, EG ;

Moses, HL .

NATURE, 2004, 432 (7015) :332-337

[5] Real-time imaging of resident T cells in human lung and ovarian carcinomas reveals how different tumor microenvironments control T lymphocyte migration [J].

Bougherara, Houcine ;

Mansuet-Lupo, Audrey ;

Alifano, Marco ;

Ngo, Charlotte ;

Damotte, Diane ;

Le Frere-Belda, Marie-Aude ;

Donnadieu, Emmanuel ;

Peranzoni, Elisa .

FRONTIERS IN IMMUNOLOGY, 2015, 6

[6]

Catto E., 2012, Box2d - a 2d physics engine for games

[7] Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation [J].

Cetera, Maureen ;

Juan, Guillermina R. Ramirez-San ;

Oakes, Patrick W. ;

Lewellyn, Lindsay ;

Fairchild, Michael J. ;

Tanentzapf, Guy ;

Gardel, Margaret L. ;

Horne-Badovinac, Sally .

NATURE COMMUNICATIONS, 2014, 5

[8] Simple model for active nematics:: Quasi-long-range order and giant fluctuations [J].

Chaté, H ;

Ginelli, F ;

Montagne, R .

PHYSICAL REVIEW LETTERS, 2006, 96 (18)

[9] Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma [J].

Conklin, Matthew W. ;

Eickhoff, Jens C. ;

Riching, Kristin M. ;

Pehlke, Carolyn A. ;

Eliceiri, Kevin W. ;

Provenzano, Paolo P. ;

Friedl, Andreas ;

Keely, Patricia J. .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (03) :1221-1232

[10]

Cox Guy, 2006, V319, P15

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