Effect of NlpE Overproduction on Multidrug Resistance in Escherichia coli

被引：35
作者：
Nishino, Kunihiko [1 ,3 ]
Yamasaki, Seiji [1 ,2 ,4 ]
Hayashi-Nishino, Mitsuko [2 ]
Yamaguchi, Akihito [2 ,4 ]
机构：
[1] Osaka Univ, Lab Microbiol & Infect Dis, Inst Sci & Ind Res, Osaka 5670047, Japan
[2] Osaka Univ, Dept Cell Membrane Biol, Inst Sci & Ind Res, Osaka 5670047, Japan
[3] Japan Sci & Technol Corp, PRESTO, Tokyo 1020075, Japan
[4] Osaka Univ, Sch Pharmaceut Sci, Osaka 5650871, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期
基金：
日本学术振兴会; 日本科学技术振兴机构;
关键词：
EXTRACYTOPLASMIC STRESS; OUTER-MEMBRANE; EFFLUX PUMPS; GENES; TRANSPORTERS; SALMONELLA; EXPRESSION; PATHWAY; TYPHIMURIUM; TOLERANCE;
D O I：
10.1128/AAC.01677-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps in Escherichia coli.
引用
收藏
页码：2239 / 2243
页数：5
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共 30 条
  • [1] The complete genome sequence of Escherichia coli K-12
    Blattner, FR
    Plunkett, G
    Bloch, CA
    Perna, NT
    Burland, V
    Riley, M
    ColladoVides, J
    Glasner, JD
    Rode, CK
    Mayhew, GF
    Gregor, J
    Davis, NW
    Kirkpatrick, HA
    Goeden, MA
    Rose, DJ
    Mau, B
    Shao, Y
    [J]. SCIENCE, 1997, 277 (5331) : 1453 - +
  • [2] The multidrug efflux protein NorM is a prototype of a new family of transporters
    Brown, MH
    Paulsen, IT
    Skurray, RA
    [J]. MOLECULAR MICROBIOLOGY, 1999, 31 (01) : 394 - 395
  • [3] The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways
    Connolly, L
    Penas, AD
    Alba, BM
    Gross, CA
    [J]. GENES & DEVELOPMENT, 1997, 11 (15) : 2012 - 2021
  • [4] One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
    Datsenko, KA
    Wanner, BL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) : 6640 - 6645
  • [5] Genome-wide profiling of promoter recognition by the two-component response regulator CpxR-P in Escherichia coli.
    De Wulf, P
    McGuire, AM
    Liu, XQ
    Lin, ECC
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (29) : 26652 - 26661
  • [6] Signal detection and target gene induction by the CpxRA two-component system
    DiGiuseppe, PA
    Silhavy, TJ
    [J]. JOURNAL OF BACTERIOLOGY, 2003, 185 (08) : 2432 - 2440
  • [7] Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli
    Fralick, JA
    [J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (19) : 5803 - 5805
  • [8] Regulation of bacterial drug export systems
    Grkovic, S
    Brown, MH
    Skurray, RA
    [J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2002, 66 (04) : 671 - +
  • [9] A Salmonella typhimurium genetic locus which confers copper tolerance on copper-sensitive mutants of Escherichia coli
    Gupta, SD
    Wu, HC
    Rick, PD
    [J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (16) : 4977 - 4984
  • [10] TIGHT REGULATION, MODULATION, AND HIGH-LEVEL EXPRESSION BY VECTORS CONTAINING THE ARABINOSE P-BAD PROMOTER
    GUZMAN, LM
    BELIN, D
    CARSON, MJ
    BECKWITH, J
    [J]. JOURNAL OF BACTERIOLOGY, 1995, 177 (14) : 4121 - 4130
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