Exosomal Non-Coding RNAs: Regulatory and Therapeutic Target of Hepatocellular Carcinoma

被引：2

作者：

Xia, Haoming ^{[1
]}

Huang, Ziyue ^{[1
]}

Liu, Shuqiang ^{[1
]}

Zhao, Xudong ^{[1
]}

He, Risheng ^{[1
]}

Wang, Zhongrui ^{[1
]}

Shi, Wenguang ^{[1
]}

Chen, Wangming ^{[1
]}

Li, Zhizhou ^{[1
]}

Yu, Liang ^{[1
,2
]}

Huang, Peng ^{[1
,2
]}

Kang, Pengcheng ^{[1
]}

Su, Zhilei ^{[1
]}

Xu, Yi ^{[1
,2
,3
]}

Yam, Judy Wai Ping ^{[3
]}

Cui, Yunfu ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Hepatopancreatobiliary Surg, Harbin, Peoples R China

[2] Harbin Med Univ, Minist Educ, Key Lab Myocardial Ischemia, Harbin, Peoples R China

[3] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pathol, Hong Kong, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国博士后科学基金;

关键词：

exosomes; non-coding RNAs; hepatocellular carcinoma; tumor microenvironment; early diagnosis; precise therapy;

D O I：

10.3389/fonc.2021.653846

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Exosomes are small extracellular vesicles secreted by most somatic cells, which can carry a variety of biologically active substances to participate in intercellular communication and regulate the pathophysiological process of recipient cells. Recent studies have confirmed that non-coding RNAs (ncRNAs) carried by tumor cell/non-tumor cell-derived exosomes have the function of regulating the cancerous derivation of target cells and remodeling the tumor microenvironment (TME). In addition, due to the unique low immunogenicity and high stability, exosomes can be used as natural vehicles for the delivery of therapeutic ncRNAs in vivo. This article aims to review the potential regulatory mechanism and the therapeutic value of exosomal ncRNAs in hepatocellular carcinoma (HCC), in order to provide promising targets for early diagnosis and precise therapy of HCC.

引用

页数：16

共 50 条

[31] Functions of exosomal non-coding RNAs to the infection with Mycobacterium tuberculosis
Wang, Jianjun
Li, Yujie
Wang, Nan
Wu, Jianhong
Ye, Xiaojian
Jiang, Yibiao
Tang, Lijun
FRONTIERS IN IMMUNOLOGY, 2023, 14
[32] The Role of Non-Coding RNAs in the Sorafenib Resistance of Hepatocellular Carcinoma
Hu, Xinyao
Zhu, Hua
Shen, Yang
Zhang, Xiaoyu
He, Xiaoqin
Xu, Ximing
FRONTIERS IN ONCOLOGY, 2021, 11
[33] The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma
Ghafouri-Fard, Soudeh
Gholipour, Mahdi
Hussen, Bashdar Mahmud
Taheri, Mohammad
FRONTIERS IN ONCOLOGY, 2021, 11
[34] Exosomal non-coding RNAs: gatekeepers of inflammation in autoimmune disease
Mohamed J. Saadh
Omer Qutaiba B. Allela
Ali Fawzi Al-Hussainy
Lalji Baldaniya
M. M. Rekha
Deepak Nathiya
Parjinder Kaur
Zafar Aminov
Hayder Naji Sameer
Huda Ghassan Hameed
Zainab H. Athab
Mohaned Adil
Journal of Inflammation, 22 (1)
[35] The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease
Liu, Jia
Wu, Junduo
Li, Longbo
Li, Tianyi
Wang, Junnan
FRONTIERS IN PHARMACOLOGY, 2020, 11
[36] Long Non-Coding RNAs: Critical Players in Hepatocellular Carcinoma
Sun, Jin
Bie, Beibei
Zhang, Shu
Yang, Jun
Li, Zongfang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (11) : 20434 - 20448
[37] The roles and therapeutic potential of exosomal non-coding RNAs in microglia-mediated intercellular communication
Yang, Hu-Bo
Lu, Ding-Ci
Shu, Min
Li, Juan
Ma, Zhaowu
INTERNATIONAL IMMUNOPHARMACOLOGY, 2025, 148
[38] Extracellular Vesicle-Related Non-Coding RNAs in Hepatocellular Carcinoma: An Overview
Augello, Giuseppa
Cusimano, Alessandra
Cervello, Melchiorre
Cusimano, Antonella
CANCERS, 2024, 16 (07)
[39] Exosomal non-coding RNAs in colorectal cancer metastasis
Yu, Xiaoqian
Bu, Chiwen
Yang, Xuejie
Jiang, Wenying
He, Xiaoyun
Sun, Ru
Guo, Hongbin
Shang, Li
Ou, Chunlin
CLINICA CHIMICA ACTA, 2024, 556
[40] Epigenetic regulation of autophagy by non-coding RNAs and exosomal non-coding RNAs in colorectal cancer: A narrative review
Liu, Minghua
Jiang, Hongfang
Momeni, Mohammad Reza
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 273

← 1 2 3 4 5 →