The lung volume reduction coil for the treatment of emphysema: a new therapy in development

被引：20

作者：

Klooster, Karin ^{[1
]}

ten Hacken, Nick H. T. ^{[1
]}

Slebos, Dirk-Jan ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, NL-9700 RB Groningen, Netherlands

来源：

EXPERT REVIEW OF MEDICAL DEVICES | 2014年 / 11卷 / 05期

关键词：

bronchoscopic lung volume reduction; COPD; emphysema; hyperinflation; interventional pulmonology; lung volume reduction; nitinol; MINIMAL IMPORTANT DIFFERENCE; THERMAL VAPOR ABLATION; MANAGEMENT; SURGERY; SEALANT; STENTS; TRIAL; VALVE;

D O I：

10.1586/17434440.2014.929490

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Lung volume reduction (LVR) coil treatment is a novel therapy for patients with severe emphysema. In this bilateral bronchoscopic treatment, approximately 10 LVR coils per lobe are delivered under fluoroscopic guidance in two sequential procedures. The LVR coil reduces lung volume by compressing the most destructed areas of the lung parenchyma and restores the lung elastic recoil. Both patients with upper-and lower-lobe predominant emphysema as well as a homogeneous emphysema distribution can be treated. LVR coil treatment results in an improvement of pulmonary function, exercise tolerance and quality of life. The LVR-coil treatment has been evaluated in several European clinical trials since 2008 and received CE mark approval in 2010. Currently, two large multicenter randomized controlled trials are underway in Europe and North America to assess the efficacy and safety of the LVR-coil treatment at 12 months compared with usual care. In this review, we share our experience with the LVR-coil treatment.

引用

页码：481 / 489

页数：9

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