SYNTHESIS OF SOME NEW THIADIAZOLE DERIVATIVES ENDOWED WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES

被引：0

作者：

Pandey, Ajit K. ^{[1
]}

Kashyap, Pranita P. ^{[1
]}

Kaur, Chanchal D. ^{[1
]}

Sawarkar, Hemant A. ^{[1
]}

Singh, Mukesh K. ^{[1
]}

机构：

[1] Shri Rawatpura Sarkar Inst Pharm, Durg 490042, Chhattisgarh, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 26卷 / 3-4期

关键词：

Analgesic; Anti-inflammatory; Schiff bases; Thiadiazole; 1,3,4-OXADIAZOLE DERIVATIVES; PHARMACOLOGICAL EVALUATION; INHIBITORS; 1-ACYLTHIOSEMICARBAZIDES; 1,3,4-THIADIAZOLES; ACID;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the present study, some new Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, H-1 NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptopheny1)-2-{N-(4-methoxybenzylidene)-4-aminopheny1}-1,3,4-thiadiazole (7f) was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence.

引用

页码：163 / 171

页数：9

共 50 条

[21] One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities
Sondhi, Sham M.
Jain, Shubhi
Dinodia, Monica
Shukla, Rakesh
Raghubir, Ram
BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (10) : 3334 - 3344
[22] A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity
Battilocchio, Claudio
Poce, Giovanna
Alfonso, Salvatore
Porretta, Giulio Cesare
Consalvi, Sara
Sautebin, Lidia
Pace, Simona
Rossi, Antonietta
Ghelardini, Carla
Mannelli, Lorenzo Di Cesare
Schenone, Silvia
Giordani, Antonio
Di Francesco, Luigia
Patrignani, Paola
Biava, Mariangela
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (13) : 3695 - 3701
[23] Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives
Alafeefy, Ahmed M.
Kadi, Adnan A.
Al-Deeb, Omar A.
El-Tahir, Kamal E. H.
Al-jaber, Nabila A.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) : 4947 - 4952
[24] Synthesis of New Nicotinic Acid Derivatives and Their Evaluation as Analgesic and Anti-inflammatory Agents
Khalil, Nadia Abdalla
Ahmed, Eman Mohamed
Mohamed, Khaled Omar
Zaitone, Sawsan Abo-Bakr
CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, 61 (09) : 933 - 940
[25] Synthesis and analgesic and anti-inflammatory activities of 7-azaindazole chalcone derivatives
Kantlam Chamakuri
Srinivasa Murthy Muppavarapu
Narsimha Reddy Yellu
Medicinal Chemistry Research, 2016, 25 : 2392 - 2398
[26] Synthesis and analgesic and anti-inflammatory activities of 7-azaindazole chalcone derivatives
Chamakuri, Kantlam
Muppavarapu, Srinivasa Murthy
Yellu, Narsimha Reddy
MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (10) : 2392 - 2398
[27] Design and synthesis of quinazolinyl acetamides for their analgesic and anti-inflammatory activities
Alagarsamy, Veerachamy
Solomon, Viswas Raja
Sulthana, Mohaideen Thasthagir
Vijay, Meduri Satyasai
Narendhar, Bandi
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2015, 70 (08): : 597 - 604
[28] Synthesis of new oxadiazole derivatives as anti-inflammatory, analgesic, and antimicrobial agents
G. C. Ramaprasad
Balakrishna Kalluraya
B. Sunil Kumar
Sahana Mallya
Medicinal Chemistry Research, 2013, 22 : 5381 - 5389
[29] Synthesis of New Pyrazole Derivatives, Their Anti-Inflammatory and Analgesic Activities, and Molecular Docking Studies
El Shehry, M. F.
Ewies, E. F.
Zayed, E. M.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (03) : 492 - 498
[30] Arylhydrazone derivatives of naproxen as new analgesic and anti-inflammatory agents: Design, synthesis and molecular docking studies
Azizian, Homa
Mousavi, Zahra
Faraji, Hamidreza
Tajik, Mohammad
Bagherzadeh, Kowsar
Bayat, Peyman
Shafiee, Abbas
Almasirad, Ali
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2016, 67 : 127 - 136

← 1 2 3 4 5 →