SYNTHESIS OF SOME NEW THIADIAZOLE DERIVATIVES ENDOWED WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES

被引：0
|
作者：
Pandey, Ajit K. [1 ]
Kashyap, Pranita P. [1 ]
Kaur, Chanchal D. [1 ]
Sawarkar, Hemant A. [1 ]
Singh, Mukesh K. [1 ]
机构：
[1] Shri Rawatpura Sarkar Inst Pharm, Durg 490042, Chhattisgarh, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 26卷 / 3-4期
关键词：
Analgesic; Anti-inflammatory; Schiff bases; Thiadiazole; 1,3,4-OXADIAZOLE DERIVATIVES; PHARMACOLOGICAL EVALUATION; INHIBITORS; 1-ACYLTHIOSEMICARBAZIDES; 1,3,4-THIADIAZOLES; ACID;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the present study, some new Schiff bases of 2,5-disubstituted-1,3,4-thiadiazole were synthesized. The chemical structures were confirmed by IR, H-1 NMR and elemental analysis. All the new compounds were tested in vivo for their analgesic and anti-inflammatory activities. Among them in particular compound 5-(2-Mercaptopheny1)-2-{N-(4-methoxybenzylidene)-4-aminopheny1}-1,3,4-thiadiazole (7f) was found to have a superior analgesic and anti-inflammatory profile with low gastric ulceration incidence.
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页码：163 / 171
页数：9
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