Effects of human chorionic gonadotropin, estradiol, and progesterone on interleukin-18 expression in human decidual tissues

被引：15

作者：

Wang, Fang ^{[1
]}

Zhu, Hong ^{[2
]}

Li, Bing ^{[1
]}

Liu, Mingxing ^{[1
]}

Liu, Dan ^{[1
]}

Deng, Meilian ^{[1
]}

Wang, Yanming ^{[3
]}

Xia, Xuefeng ^{[1
]}

Jiang, Qingping ^{[1
]}

Chen, Dunjin ^{[1
]}

机构：

[1] Guangzhou Med Univ, Affiliated Hosp 3, Key Lab Major Obstet Dis Guangdong Prov, 63 Duobao Rd, Guangzhou 510145, Guangdong, Peoples R China

[2] Peoples Hosp Jiangmen, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China

[3] Yanan Univ, Dept Gynecol & Obstet, Affiliated Hosp, Yanan, Peoples R China

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2017年 / 33卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Interleukin-18; spontaneous abortion; uterine natural killer cell; RECURRENT MISCARRIAGE; NK CELLS; PREGNANCY; WOMEN; IL-18; POLYMORPHISMS; ENDOMETRIUM; ACTIVATION; FAILURE; HISTORY;

D O I：

10.1080/09513590.2016.1212829

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin (IL)-18 is a proinflammatory cytokine which mediates a myriad of inflammatory responses during pregnancy. Changes in IL-18 levels have been linked to complications during pregnancy. This study was designed to assess the effects of estradiol, human chorionic gonadotropin (hCG), and progesterone on IL-18 expression in human decidual tissues. Uterine deciduas from women with normal pregnancy, spontaneous abortion, and progesterone treated spontaneous abortion were collected, and the effects of hormones on the viability of decidual cells and IL-18 secretion were detected by MTT and ELISA assays. We found that Estradiol, hCG, and progesterone inhibited decidual cell growth independent of dosage and time.IL-18 secretion in the spontaneous abortion group was increased in the decidual cells over time, but all hormones significantly reduced its secretion (p<0.05). Our results indicate that estradiol, hCG, and progesterone can reduce IL-18 secretion in the cultured endometrial stromal cells from patients who experienced spontaneous abortion to the levels observed following normal pregnancy. Progesterone can significantly reduce IL-18 expression and increase growth of CD56+ CD16- uNK cells, suggesting that these activities may underlie the mechanism by which progesterone improves pregnancy outcomes.

引用

页码：265 / 269

页数：5

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