Syndecans in angiogenesis and endothelial cell biology

被引：25
|
作者：
De Rossi, Giulia [1 ]
Whiteford, James R. [1 ]
机构：
[1] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Ctr Microvasc Res, Charterhouse Sq, London EC1M 6B, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2014年 / 42卷
关键词：
angiogenesis; endothelial cell; heparan sulfate; integrin; syndecan; FACTOR-I RECEPTOR; REGULATES ALPHA(V)BETA(3); INTEGRIN ACTIVITY; WOUND REPAIR; ACTIVATION;
D O I：
10.1042/BST20140232
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Syndecans are multifunctional heparan sulfate proteoglycans (HSPGs) with roles in cell adhesion, migration, receptor trafficking and growth-factor interactions and signalling. Studies using syndecan null animals have revealed limited roles for syndecans during development; however, under conditions of challenge or insult, several phenotypes have emerged. Angiogenesis is an important process both in development and in wound healing, but also in pathologies such as cancer and chronic inflammatory conditions. In the present paper, we summarize the main studies elucidating the role of syndecans in angiogenesis and their potential as novel therapeutic targets.
引用
收藏
页码：1643 / 1646
页数：4
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