Genome Sequence of a Recently Emerged, Highly Transmissible, Multi-Antibiotic- and Antiseptic-Resistant Variant of Methicillin-Resistant Staphylococcus aureus, Sequence Type 239 (TW)

被引：147

作者：

Holden, Matthew T. G. ^{[1
]}

Lindsay, Jodi A. ^{[2
]}

Corton, Craig ^{[1
]}

Quail, Michael A. ^{[1
]}

Cockfield, Joshua D. ^{[2
]}

Pathak, Smriti ^{[3
]}

Batra, Rahul ^{[4
]}

Parkhill, Julian ^{[1
]}

Bentley, Stephen D. ^{[1
]}

Edgeworth, Jonathan D. ^{[3
,4
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[2] Univ London, Ctr Infect, Dept Cellular & Mol Med, London, England

[3] Kings Coll London, Guys Kings & St Thomas Med Sch, Guys Hosp, Dept Infect Dis, London WC2R 2LS, England

[4] Guys & St Thomas NHS Fdn Trust, Directorate Infect, London, England

来源：

JOURNAL OF BACTERIOLOGY | 2010年 / 192卷 / 03期

基金：

英国惠康基金;

关键词：

NUCLEOTIDE-SEQUENCE; EVOLUTION; STRAIN; IDENTIFICATION; EPIDERMIDIS; VIRULENCE; PROTEINS; CLONE; GENE; CHROMOSOME;

D O I：

10.1128/JB.01255-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 3.1-Mb genome of an outbreak methicillin-resistant Staphylococcus aureus (MRSA) strain (TW20) contains evidence of recently acquired DNA, including two large regions ( 635 kb and 127 kb). The strain is resistant to a wide range of antibiotics, antiseptics, and heavy metals due to resistance genes encoded on mobile genetic elements and also mutations in housekeeping genes.

引用

页码：888 / 892

页数：5

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