Immunological Risk Factors in Recurrent Pregnancy Loss: Guidelines Versus Current State of the Art

被引：64
作者：
Vomstein, Kilian [1 ]
Feil, Katharina [1 ]
Strobel, Laura [1 ]
Aulitzky, Anna [1 ]
Hofer-Tollinger, Susanne [1 ]
Kuon, Ruben-Jeremias [2 ]
Toth, Bettina [1 ]
机构：
[1] Med Univ Innsbruck, Dept Gynecol Endocrinol & Reprod Med, Anichstr 35, A-6020 Innsbruck, Austria
[2] Heidelberg Univ, Dept Gynecol Endocrinol & Fertil Disorders, Neuenheimer Feld 440, D-69120 Heidelberg, Germany
来源：
JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 04期
基金：
奥地利科学基金会;
关键词：
recurrent miscarriage; reproductive immunology; NK cells; regulatory T cells; REGULATORY T-CELLS; NATURAL-KILLER-CELLS; IN-VITRO FERTILIZATION; COLONY-STIMULATING FACTOR; PLACEBO-CONTROLLED TRIAL; HLA-C GENES; INTRAVENOUS IMMUNOGLOBULIN; CHRONIC ENDOMETRITIS; SPONTANEOUS-ABORTION; DOUBLE-BLIND;
D O I：
10.3390/jcm10040869
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Around 1-5% of all couples experience recurrent pregnancy loss (RPL). Established risk factors include anatomical, genetic, endocrine, and hemostatic alterations. With around 50% of idiopathic cases, immunological risk factors are getting into the scientific focus, however international guidelines hardly take them into account. Within this review, the current state of immunological risk factors in RPL in international guidelines of the European Society of Reproduction and Embryology (ESHRE), American Society of Reproductive Medicine (ASRM), German/Austrian/Swiss Society of Obstetrics and Gynecology (DGGG/OEGGG/SGGG) and the Royal College of Obstetricians and Gynecologists (RCOG) are evaluated. Special attention was drawn to recommendations in the guidelines regarding diagnostic factors such as autoantibodies, natural killer cells, regulatory T cells, dendritic cells, plasma cells, and human leukocyte antigen system (HLA)-sharing as well as treatment options such as corticosteroids, intralipids, intravenous immunoglobulins, aspirin and heparin in RPL. Finally, the current state of the art focusing on both diagnostic and therapeutic options was summarized.
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页码：1 / 21
页数：21
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