Impact of IDH1 c.315C>T SNP on Outcomes in Acute Myeloid Leukemia: A Propensity Score-Adjusted Cohort Study

被引：3

作者：

Corley, Elizabeth M. ^{[1
]}

Ali, Moaath K. Mustafa ^{[2
,3
]}

Alharthy, Hanan ^{[3
]}

Kline, Kathryn A. F. ^{[2
,3
]}

Sewell, Danielle ^{[4
]}

Law, Jennie Y. ^{[2
,3
]}

Lee, Seung Tae ^{[2
,3
]}

Niyongere, Sandrine ^{[2
,3
]}

Duong, Vu H. ^{[2
,3
]}

Baer, Maria R. ^{[2
,3
]}

Emadi, Ashkan ^{[2
,3
,4
,5
]}

机构：

[1] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[2] Univ Maryland, Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[4] Univ Maryland, Greenebaum Comprehens Canc Ctr, Translat Genom Lab, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

AML; IDH1; c; 315C > T SNP; prognosis; survival; Myeloid mutations; RECOMMENDATIONS; MANAGEMENT; MUTATIONS; DIAGNOSIS; AML;

D O I：

10.3389/fonc.2022.804961

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is the common type of acute leukemia in adults. Definitive prognostic significance of variants of unknown significance lacks for many commonly mutated genes, including the isocitrate dehydrogenase 1 (IDH1) synonymous single nucleotide polymorphism (SNP) variant c.315C>T. In this retrospective cohort study of 248 AML patients at the University of Maryland Greenebaum Comprehensive Cancer Center, we show that the IDH1 c.315C>T SNP, previously reported to be associated with poor prognosis by other studies with conflicting data, does not confer worse prognosis, with a median overall survival (OS) of 17.1 months compared to 15.1 months for patients without this SNP (P=0.57). The lack of negative effect on prognosis by IDH1 SNP c.315C>T is consistent with the absence of amino acid alteration (p.Gly105Gly).

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页数：6

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