Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection

被引：39
|
作者：
Wenger, Jerome [1 ]
Rigneault, Herve [1 ]
机构：
[1] Aix Marseille Univ, Inst Fresnel, CNRS, Ecole Cent Marseille, F-13397 Marseille 20, France
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 01期
关键词：
single molecule; fluorescence correlation spectroscopy FCS; nanophotonics; biophotonics; MODE WAVE-GUIDES; TOTAL INTERNAL-REFLECTION; SOLID IMMERSION LENS; DIELECTRIC MICROSPHERES; NANOMETRIC APERTURES; FIELD CONFINEMENT; FLUIDIC CHANNELS; MICROSCOPE; DIFFUSION; EXCITATION;
D O I：
10.3390/ijms11010206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in nanophotonics open the way for promising applications towards efficient single molecule fluorescence analysis. In this review, we discuss how photonic methods bring innovative solutions for two essential questions: how to detect a single molecule in a highly concentrated solution, and how to enhance the faint optical signal emitted per molecule? The focus is set primarily on the widely used technique of fluorescence correlation spectroscopy (FCS), yet the discussion can be extended to other single molecule detection methods.
引用
收藏
页码：206 / 221
页数：16
相关论文
共 50 条
  • [31] Probing redox proteins on a gold surface by single molecule fluorescence spectroscopy
    Elmalk, Abdalmohsen T.
    Salverda, Jante M.
    Tabares, Leandro C.
    Canters, Gerard W.
    Aartsma, Thijs J.
    JOURNAL OF CHEMICAL PHYSICS, 2012, 136 (23)
  • [32] Dual-Focus Fluorescence Correlation Spectroscopy
    Pieper, Christoph
    Weiss, Kerstin
    Gregor, Ingo
    Enderlein, Joerg
    FLUORESCENCE FLUCTUATION SPECTROSCOPY (FFS), PT A, 2013, 518 : 175 - 204
  • [33] Single-molecule spectroscopy and fluorescence correlation spectroscopy of the lateral transport of the T3 promoter primer at a chemical interface
    Wirth, MJ
    Swinton, DJ
    APPLIED SPECTROSCOPY, 2001, 55 (08) : 1013 - 1017
  • [34] Fluorescence Correlation Spectroscopy as a Versatile Method to Define Aptamer-Protein Interactions with Single-Molecule Sensitivity
    Porciani, David
    Alampi, Manuela Maria
    Abbruzzetti, Stefania
    Viappiani, Cristiano
    Delcanale, Pietro
    ANALYTICAL CHEMISTRY, 2023, 96 (01) : 137 - 144
  • [35] High-sensitivity Single Molecule Fluorescence Detection Using Scanning Single-Molecule Counting
    Yamaguchi, Mitsushiro
    Tanabe, Tetsuya
    Nakata, Hidetaka
    Hanashi, Takuya
    Nishikawa, Kazutaka
    Hori, Kunio
    Kondo, Seiji
    MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES XIV, 2014, 8948
  • [36] Fluorescence Correlation Spectroscopy: A Review of Biochemical and Microfluidic Applications
    Yu Tian
    Martinez, Michelle M.
    Pappas, Dimitri
    APPLIED SPECTROSCOPY, 2011, 65 (04) : 115A - 124A
  • [37] Detection method for quantifying global DNA methylation by fluorescence correlation spectroscopy
    Umezu, Tomohiro
    Ohyashiki, Kazuma
    Ohyashiki, Junko H.
    ANALYTICAL BIOCHEMISTRY, 2011, 415 (02) : 145 - 150
  • [38] Confined detection volume of fluorescence correlation spectroscopy by bare fiber probes
    Lu, Guowei
    Lei, Franck H.
    Angiboust, Jean-Francois
    Manfait, Michel
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2010, 39 (05): : 855 - 860
  • [39] Fluorescence correlation spectroscopy in polymer science
    Woell, Dominik
    RSC ADVANCES, 2014, 4 (05): : 2447 - 2465
  • [40] Fluorescence Correlation Spectroscopy of Gold Nanoparticles
    Balaji, P. Sri
    Murthy, A. V. R.
    Tiwari, Neha
    Kulkarni, Sulabha
    SPECTROSCOPY LETTERS, 2012, 45 (01) : 22 - 28
12345