A psychobiotic approach to the treatment of depression: A systematic review and meta-analysis

被引：14

作者：

Zhu, Huiyue ^{[1
,2
]}

Tian, Peijun ^{[1
,2
]}

Zhao, Jianxin ^{[1
,2
,3
,4
]}

Zhang, Hao ^{[1
,2
,3
,4
,5
,6
]}

Wang, Gang ^{[1
,2
,3
,4
]}

Chen, Wei ^{[1
,2
,5
,6
]}

机构：

[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[3] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China

[4] Jiangnan Univ, Yangzhou Inst Food Biotechnol, Yangzhou 225004, Jiangsu, Peoples R China

[5] Wuxi Translat Med Res Ctr, Wuxi, Jiangsu, Peoples R China

[6] Jiangsu Translat Med Res Inst, Wuxi Branch, Wuxi, Jiangsu, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2022年 / 91卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Depression; Probiotics; Psychobiotics; Meta-analysis; Randomized controlled trial; DOUBLE-BLIND; GUT MICROBIOME; PROBIOTIC TREATMENT; MAJOR DEPRESSION; LACTOBACILLUS; BIFIDOBACTERIUM; DISORDER; CITALOPRAM; BEHAVIORS; STRESS;

D O I：

10.1016/j.jff.2022.104999

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

A meta-analysis based on randomized controlled trials was conducted to clarify the effect of psychobiotics on depression in adults. The main result of concern is the score of the psychometric questionnaires. The outcomes were extracted using standardized mean difference (SMD) from each study, based on a random-effects model. Psychobiotic treatment results in a higher depression score reduction compared with the placebo. The observed SMDs ranged from -0.673 to 1.011, with most estimates being positive (63%). The estimated average SMD based on the random-effects model was 0.19 (95% confidence interval: 0.01-0.37), with the average outcome differed significantly from zero (Z = 2.018, P = 0.044). The subgroup analysis indicated that psychobiotics are advisable to be delivered in solid formulations with multiple probiotic strains and used in age-appropriate depressed patients. Collectively, psychobiotics showed great potential in managing mental health when appropriately administered.

引用

页数：7

共 49 条

[1] Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats [J].

Ait-Belgnaoui, Afifa ;

Durand, Henri ;

Cartier, Christel ;

Chaumaz, Gilles ;

Eutamene, Helene ;

Ferrier, Laurent ;

Houdeau, Eric ;

Fioramonti, Jean ;

Bueno, Lionel ;

Theodorou, Vassilia .

PSYCHONEUROENDOCRINOLOGY, 2012, 37 (11) :1885-1895

[2] Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder [J].

Aizawa, Emiko ;

Tsuji, Hirokazu ;

Asahara, Takashi ;

Takahashi, Takuya ;

Teraishi, Toshiya ;

Yoshida, Sumiko ;

Ota, Miho ;

Koga, Norie ;

Hattori, Kotaro ;

Kunugi, Hiroshi .

JOURNAL OF AFFECTIVE DISORDERS, 2016, 202 :254-257

[3] Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial [J].

Akkasheh, Ghodarz ;

Kashani-Poor, Zahra ;

Tajabadi-Ebrahimi, Maryam ;

Jafari, Parvaneh ;

Akbari, Hossein ;

Taghizadeh, Mohsen ;

Memarzadeh, Mohammad Reza ;

Asemi, Zatollah ;

Esmaillzadeh, Ahmad .

NUTRITION, 2016, 32 (03) :315-320

[4] Major depressive disorder [J].

Otte, Christian ;

Gold, Stefan M. ;

Penninx, Brenda W. ;

Pariante, Carmine M. ;

Etkin, Amit ;

Fava, Maurizio ;

Mohr, David C. ;

Schatzberg, Alan F. .

NATURE REVIEWS DISEASE PRIMERS, 2016, 2

[5] The gut microbiota influences blood-brain barrier permeability in mice [J].

Braniste, Viorica ;

Al-Asmakh, Maha ;

Kowal, Czeslawa ;

Anuar, Farhana ;

Abbaspour, Afrouz ;

Toth, Miklos ;

Korecka, Agata ;

Bakocevic, Nadja ;

Ng, Lai Guan ;

Kundu, Parag ;

Gulyas, Balazs ;

Halldin, Christer ;

Hultenby, Kjell ;

Nilsson, Harriet ;

Hebert, Hans ;

Volpe, Bruce T. ;

Diamond, Betty ;

Pettersson, Sven .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (263)

[6] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].

Bravo, Javier A. ;

Forsythe, Paul ;

Chew, Marianne V. ;

Escaravage, Emily ;

Savignac, Helene M. ;

Dinan, Timothy G. ;

Bienenstock, John ;

Cryan, John F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055

[7] Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders [J].

Bravo, Javier A. ;

Dinan, Timothy G. ;

Cryan, John F. .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2011, 14 (05) :666-683

[8] Gut feelings: A randomised, triple-blind, placebo-controlled trial of probiotics for depressive symptoms [J].

Chahwan, Bahia ;

Kwan, Sophia ;

Isik, Ashling ;

van Hemert, Saskia ;

Burke, Catherine ;

Roberts, Lynette .

JOURNAL OF AFFECTIVE DISORDERS, 2019, 253 :317-326

[9] Systematic Review of Gut Microbiota and Major Depression [J].

Cheung, Stephanie G. ;

Goldenthal, Ariel R. ;

Uhlemann, Anne-Catrin ;

Mann, J. John ;

Miller, Jeffrey M. ;

Sublette, M. Elizabeth .

FRONTIERS IN PSYCHIATRY, 2019, 10

[10] Fermented milk of Lactobacillus helveticus IDCC3801 improves cognitive functioning during cognitive fatigue tests in healthy older adults [J].

Chung, Young-Chul ;

Jin, Hong-Mei ;

Cui, Yin ;

Kim, Dal Sik ;

Jung, Jin Mu ;

Park, Jong-Il ;

Jung, Eun-Soo ;

Choi, Eun-Kyung ;

Chae, Soo-Wan .

JOURNAL OF FUNCTIONAL FOODS, 2014, 10 :465-474

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