Solvent Free Microwave Accelerated Synthesis of Heterocyclic Thiazolidin-4-ones as Antimicrobial and Antifungal Agents

被引：7
作者：
Sekhar, Kondapalli Venkata Gowri Chandra [1 ]
Rao, Vajja Sambasiva [1 ]
Reddy, Aravalli Satish [2 ]
Sunandini, Ravada [2 ]
Satuluri, V. S. A. Kumar [2 ]
机构：
[1] BITS, Chem Grp, Hyderabad 500078, Andhra Pradesh, India
[2] BITS, Chem Grp, Pilani 333031, Rajasthan, India
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2010年 / 31卷 / 05期
关键词：
Quinoxalines; Silica; Microwave irradiation; Antibacterial; Antifungal; ANTI-MICROBIAL ACTIVITY; CHEMISTRY;
D O I：
10.5012/bkcs.2010.31.5.1219
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and efficient method has been developed for conversion of arenecarbaldehyde-3-methylquinoxalin-2-yl-hydrazones to 3-(2-methylquinoxalin-3-yl)-2-(substitutedphenyl)thiazolidin-4-ones in good yields using microwave irradiation technique on silica as solid support under solvent free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, H-1 NMR, and mass spectroscopy. All the synthesized thiazolidinones were investigated for their antimicrobial and anti fungal activities. The results of the biological activities revealed that the compounds 3b, 3d, 3f and 3h exhibited excellent antibacterial activities while 3d and 3h exhibited good antifungal activity.
引用
收藏
页码：1219 / 1222
页数：4
相关论文
共 50 条
  • [41] Synthesis of new pyrazine-pyrazole-thiazolidin-4-one and pyrazine-triazole-thiazolidin-4-one conjugates, molecular modelling and docking as antimicrobial agents
    Alsimaree, Abdulrahman A.
    Alessa, Ali H.
    Alharbi, Arwa
    Obaid, Najla A.
    Alshammari, Nawaa Ali H.
    Qurban, Jihan
    Abumelha, Hana M.
    El-Metwaly, Nashwa M.
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1320
  • [42] Efficient Regioselective Three-Component Domino Synthesis of 3-(1,2,4-Triazol-5-yl)-1,3-thiazolidin-4-ones as Potent Antifungal and Antituberculosis Agents
    El Bialy, Serry A.
    Nagy, Maria M.
    Abdel-Rahman, Hamdy M.
    ARCHIV DER PHARMAZIE, 2011, 344 (12) : 821 - 829
  • [43] Synthesis of 3-[3-(Benzothiazol-2-yl)-4-oxo-thiazolidin-2-yl]chromones as Antifungal Agents
    Sharma, Vinay Prabha
    Kumar, Praveen
    Sharma, Meenakshi
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (10) : 4616 - 4620
  • [44] 2-Aryl-3-(2-morpholinoethyl)thiazolidin-4-ones: Synthesis, anti-inflammatory in vivo, cytotoxicity in vitro and molecular docking studies
    Gouvea, Daniela Pires
    Vasconcellos, Flavia Aleixo
    Berwaldt, Gabriele dos Anjos
    Pinto Seixas Neto, Amilton Clair
    Fischer, Gerferson
    Sakata, Renata Parruca
    Almeida, Wanda Pereira
    Cunico, Wilson
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 118 : 259 - 265
  • [45] Microwave-Assisted Solvent-Free Synthesis of N-alkyl Benzotriazole Derivatives: Antimicrobial Studies
    Ningegowda, Raghu
    Kavitha, C. V.
    Priya, B. S.
    Gaonkar, S. L.
    Tejesvi, M. V.
    Rangappa, K. S.
    Swamy, S. Nanjunda
    LETTERS IN DRUG DESIGN & DISCOVERY, 2009, 6 (07) : 502 - 507
  • [46] Clean and efficient microwave solvent-free synthesis of some antimicrobial compounds from 2-aminothiadiazine
    Patel, VM
    Desai, KR
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2005, 44 (10): : 2158 - 2162
  • [47] Solvent-free synthesis of nitrilotriacetamide and diketopiperazines from nitrilotriacetic acid under microwave irradiation and their antimicrobial activity
    Oeztuerk, Guelsen
    Guemguem, Bahattin
    Kizil, Murat
    Emen, Sevil
    SYNTHETIC COMMUNICATIONS, 2007, 37 (22-24) : 3981 - 3988
  • [48] Microwave Synthesis of New Pyrazolo[3,4-d]pyrimidin-4-ones in Solvent-Free Condition
    Davoodnia, A.
    Anvari, L.
    Tavakoli-Hoseini, N.
    ASIAN JOURNAL OF CHEMISTRY, 2011, 23 (08) : 3683 - 3685
  • [49] SOLVENT-FREE MICROWAVE ACCELERATED SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF PHTHALIDE-FUSED INDOLINES
    Sheryn, Wong
    Ngah, Fatimatul Akma Awang
    Latip, Jalifah
    Hassan, Nurul Izzaty
    Hasbullah, Siti Aishah
    HETEROCYCLES, 2018, 96 (05) : 841 - 851
  • [50] Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10-undecenoic acid hydrazide
    Rahman, VPM
    Mukhtar, S
    Ansari, WH
    Lemiere, G
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (02) : 173 - 184
12345