Solvent Free Microwave Accelerated Synthesis of Heterocyclic Thiazolidin-4-ones as Antimicrobial and Antifungal Agents

被引：7

作者：

Sekhar, Kondapalli Venkata Gowri Chandra ^{[1
]}

Rao, Vajja Sambasiva ^{[1
]}

Reddy, Aravalli Satish ^{[2
]}

Sunandini, Ravada ^{[2
]}

Satuluri, V. S. A. Kumar ^{[2
]}

机构：

[1] BITS, Chem Grp, Hyderabad 500078, Andhra Pradesh, India

[2] BITS, Chem Grp, Pilani 333031, Rajasthan, India

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2010年 / 31卷 / 05期

关键词：

Quinoxalines; Silica; Microwave irradiation; Antibacterial; Antifungal; ANTI-MICROBIAL ACTIVITY; CHEMISTRY;

D O I：

10.5012/bkcs.2010.31.5.1219

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient method has been developed for conversion of arenecarbaldehyde-3-methylquinoxalin-2-yl-hydrazones to 3-(2-methylquinoxalin-3-yl)-2-(substitutedphenyl)thiazolidin-4-ones in good yields using microwave irradiation technique on silica as solid support under solvent free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, H-1 NMR, and mass spectroscopy. All the synthesized thiazolidinones were investigated for their antimicrobial and anti fungal activities. The results of the biological activities revealed that the compounds 3b, 3d, 3f and 3h exhibited excellent antibacterial activities while 3d and 3h exhibited good antifungal activity.

引用

页码：1219 / 1222

页数：4

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