A Sensitive Fluorescent Probe for Cysteine Based on 1,8-Naphthalimide Derivative and Application in Bioimaging

被引：5
|
作者：
Yang Jingjing [1 ]
Yu Yuewen [1 ]
Wang Bingxiang [1 ]
Jiang Yuliang [1 ]
机构：
[1] Nanjing Normal Univ, Coll Chem & Mat Sci, Jiangsu Prov Engn Res Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Biofunct Mat, Nanjing 210046, Jiangsu, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2017年 / 38卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Fluorescent probe; Cysteine; Cells imaging; 1,8-Naphthalimide derivative; NAKED-EYE; SENSOR; HOMOCYSTEINE; IRON; HOST; CU2+; FE3+; PH;
D O I：
10.7503/cjcu20160960
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A turn. on fluorescent probe glyoxal mono (N-hydroxyethyl. 1, 8-naphthalimide-4-hydrazone) (NAD) was designed and synthesized for the detection of cysteine(Cys). The fluorescent probe shows high selectivity and sensitivity toward Cys over other various amino acids. When Cys was added to the solution of the probe, the C = N isomerization process was inhibited by an intramolecular hydrogen bond, resulting in enhanced fluorescence. Furthermore, the probe NAD could effectively detect Cys in living cells.
引用
收藏
页码：1198 / 1202
页数：5
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共 34 条
  • [1] Application of a bismuth film electrode to the voltammetric determination of trace iron using a Fe(III)-TEA-BrO3- catalytic system
    Bobrowski, A
    Nowak, K
    Zarebski, J
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2005, 382 (07) : 1691 - 1697
  • [2] A facile approach to β-amino acid derivatives via palladium-catalyzed hydrocarboxylation of enimides with formic acid
    Dai, Jie
    Ren, Wenlong
    Wang, Haining
    Shi, Yian
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (31) : 8429 - 8432
  • [3] Signaling recognition events with fluorescent sensors and switches
    de Silva, AP
    Gunaratne, HQN
    Gunnlaugsson, T
    Huxley, AJM
    McCoy, CP
    Rademacher, JT
    Rice, TE
    [J]. CHEMICAL REVIEWS, 1997, 97 (05) : 1515 - 1566
  • [4] Naked-eye and fluorescence detection of basic pH and F- with a 1,8-naphthalimide-based multifunctional probe
    Du, Weiwei
    Xu, Jie
    Li, Haixia
    Feng, Chengcheng
    Yu, Mingming
    Li, Zhanxian
    Wei, Liuhe
    [J]. RSC ADVANCES, 2015, 5 (20): : 15077 - 15083
  • [5] Theoretical investigation of the directional electron transfer in 4-aminonaphthalimide compounds
    Gao, YQ
    Marcus, RA
    [J]. JOURNAL OF PHYSICAL CHEMISTRY A, 2002, 106 (10): : 1956 - 1960
  • [6] Study on optical sensing composites for cysteine detection using an up-conversion excitation host and two rhodamine derived chemosensors
    Jia, Huali
    Ren, Kai
    Wang, Xin
    Li, Limin
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2016, 228 : 308 - 316
  • [7] Sequential colorimetric recognition of Cu2+ and CN- by asymmetric coumarin-conjugated naphthol groups in aqueous solution
    Jo, Hyun Yong
    Park, Gyeong Jin
    Na, Yu Jeong
    Choi, Ye Won
    You, Ga Rim
    Kim, Cheal
    [J]. DYES AND PIGMENTS, 2014, 109 : 127 - 134
  • [8] Spontaneous formation and amplification of an enantioenriched α-amino nitrile: a chiral precursor for Strecker amino acid synthesis
    Kawasaki, Tsuneomi
    Takamatsu, Naoya
    Aiba, Shohei
    Tokunaga, Yuji
    [J]. CHEMICAL COMMUNICATIONS, 2015, 51 (76) : 14377 - 14380
  • [9] Rhodamine Triazole-Based Fluorescent Probe for the Detection of Pt2+
    Kim, Hyemi
    Lee, Sunho
    Lee, Jihyun
    Tae, Jinsung
    [J]. ORGANIC LETTERS, 2010, 12 (22) : 5342 - 5345
  • [10] Calixarene-derived fluorescent probes
    Kim, Jong Seung
    Quang, Duong Tuan
    [J]. CHEMICAL REVIEWS, 2007, 107 (09) : 3780 - 3799
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