Synthesis, Crystal Structure, Antioxidant Activity, and DNA-Binding Studies of a Novel Ni(II) [2x2] Grid Complex with a Rigid Bistridentate Schiff Base Ligand

被引：7

作者：

Jia, Lei ^{[2
,3
]}

Xu, Jun ^{[2
]}

Xu, Xi-Ming ^{[1
]}

Chen, Long-Hai ^{[2
]}

Jiang, Peng ^{[1
]}

Cheng, Fei-Xiang ^{[2
]}

Lu, Guang-Nong ^{[2
]}

Wang, Qin ^{[1
]}

Wu, Jin-Cai ^{[2
]}

Tang, Ning ^{[2
]}

机构：

[1] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

[3] Henan Polytech Univ, Dept Chem & Phys, Jiaozuo 454000, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 08期

关键词：

crystal structure; Ni(II) complex; intercalation binding; antioxidant activity; METAL-IONS; CHEMISTRY;

D O I：

10.1248/cpb.58.1077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With a bistridentate Schiff-base ligand, N',N'(3)-bis[(1E)-1-(2-pyridinyl)ethylidene)] isophthalohydrazide (H2L), a [2x2]G grid complex, [Ni-4(HL)(4)](ClO4)(4)center dot 4H(2)O center dot 0.5 CH3OH (1) has been synthesized and characterized spectroscopically and crystallographically. Spectrometric titrations, ethidium bromide displacement experiments, circular dichroism spectral analysis and viscosity measurements indicate that the compound I strongly binds with calf-thymus DNA, presumably via intercalation mechanism. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its nickel(11) complex is determined by using spectrophotometer methods in vitro. Complex 1 is found to possess potent antioxidant activity and be better than standard antioxidants like mannitol.

引用

页码：1077 / 1080

页数：4

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