Chronic stress alters the expression levels of longevity-related genes in the rat hippocampus

被引：15

作者：

Sanchez-Hidalgo, Ana C. ^{[1
]}

Munoz, Mario F. ^{[2
,3
]}

Herrera, Antonio J. ^{[2
,3
]}

Espinosa-Oliva, Ana M. ^{[2
,3
]}

Stowell, Rianne ^{[4
]}

Ayala, Antonio ^{[2
,3
]}

Machado, Alberto ^{[2
,3
]}

Venero, Jose L. ^{[2
,3
]}

de Pablos, Rocio M. ^{[2
,3
]}

机构：

[1] Univ Seville, Dept Fisiol Med & Biofis, Seville 41013, Spain

[2] Univ Seville, Inst Biomed Sevilla IBiS, Hosp Univ Virgen del Rocio, CSIC, Seville 41013, Spain

[3] Univ Seville, Fac Farm, Dept Bioquim & Biol Mol, Calle Prof Garcia Gonzalez 2, Seville 41012, Spain

[4] Univ Rochester, Med Ctr, Dept Neurosci, 607 Elmwood Ave,Box 603, Rochester, NY 14642 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 2016年 / 97卷

关键词：

Chronic stress; Glucocorticoids; Hippocampus; Oxidative stress; RU486; Sirtuins; CHRONIC PSYCHOLOGICAL STRESS; NADPH-OXIDASE ACTIVATION; PITUITARY-ADRENAL AXIS; HEAT-SHOCK RESPONSE; OXIDATIVE STRESS; LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; SYNAPTIC PLASTICITY; POTENTIAL ROLE; MILD STRESS;

D O I：

10.1016/j.neuint.2016.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular mechanisms underlying the negative effects of psychological stress on cellular stress during aging and neurodegenerative diseases are poorly understood. The main objective of this study was to test the effect of chronic psychological stress, and the consequent increase of circulating glucocorticoids, on several hippocampal genes involved in longevity. Sirtuin-1, p53, thioredoxin-interacting protein, and heat shock protein 70 were studied at the mRNA and protein levels in stressed and non stressed animals. Stress treatment for 10 days decreased sirtuin-1 and heat shock protein 70 levels, but increased levels of p53, thioredoxin-interacting protein and the NADPH oxidase enzyme. Examination of protein expression following two months of stress treatment indicated, that sirtuin-1 remained depressed. In contrast, an increase was observed for thioredoxin-interacting protein, heat shock protein 70, p53 and the NADPH oxidase enzyme. The effect of stress was reversed by mifepristone, a glucocorticoid receptor antagonist. These data suggest that chronic stress could contribute to aging in the hippocampus. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：181 / 192

页数：12

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