Regulation of cell death: The calcium-apoptosis link

被引：2447
作者：
Orrenius, S
Zhivotovsky, B
Nicotera, P
机构：
[1] Karolinska Inst, Div Toxicol, Inst Environm Med, SE-17177 Stockholm, Sweden
[2] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 07期
关键词：
D O I：
10.1038/nrm1150
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms - survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.
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页码：552 / 565
页数：14
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共 141 条
[1]   Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan [J].
Akao, Y ;
Maruyama, W ;
Shimizu, S ;
Yi, H ;
Nakagawa, Y ;
Shamoto-Nagai, M ;
Youdim, MBH ;
Tsujimoto, Y ;
Naoi, M .
JOURNAL OF NEUROCHEMISTRY, 2002, 82 (04) :913-923
[2]   Cytokines and acute neurodegeneration [J].
Allan, SM ;
Rothwell, NJ .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (10) :734-744
[3]   Human ICE/CED-3 protease nomenclature [J].
Alnemri, ES ;
Livingston, DJ ;
Nicholson, DW ;
Salvesen, G ;
Thornberry, NA ;
Wong, WW ;
Yuan, JY .
CELL, 1996, 87 (02) :171-171
[4]   Inhibition of Bax channel-forming activity by Bcl-2 [J].
Antonsson, B ;
Conti, F ;
Ciavatta, A ;
Montessuit, S ;
Lewis, S ;
Martinou, I ;
Bernasconi, L ;
Bernard, A ;
Mermod, JJ ;
Mazzei, G ;
Maundrell, K ;
Gambale, F ;
Sadoul, R ;
Martinou, JC .
SCIENCE, 1997, 277 (5324) :370-372
[5]   Annexin I is an endogenous ligand that mediates apoptotic cell engulfment [J].
Arur, S ;
Uche, UE ;
Rezaul, K ;
Fong, M ;
Scranton, V ;
Cowan, AE ;
Mohler, W ;
Han, DK .
DEVELOPMENTAL CELL, 2003, 4 (04) :587-598
[6]   Aminophospholipid asymmetry: A matter of life and death [J].
Balasubramanian, K ;
Schroit, AJ .
ANNUAL REVIEW OF PHYSIOLOGY, 2003, 65 :701-734
[7]   Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks [J].
Beresford, PJ ;
Zhang, D ;
Oh, DY ;
Fan, ZS ;
Greer, EL ;
Russo, ML ;
Jaju, M ;
Lieberman, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (46) :43285-43293
[8]   The versatility and universality of calcium signalling [J].
Berridge, MJ ;
Lipp, P ;
Bootman, MD .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (01) :11-21
[9]   INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING [J].
BERRIDGE, MJ .
NATURE, 1993, 361 (6410) :315-325
[10]   Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death [J].
Boldin, MP ;
Goncharov, TM ;
Goltsev, YV ;
Wallach, D .
CELL, 1996, 85 (06) :803-815
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